Analytical Data
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基因名
HDAC6
- Application
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别名
HDAC6；KIAA0901；Histone deacetylase 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBN7
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表达区间
1-1215aa
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氨基酸序列
MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELG LEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAV LDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVT HPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYI AWPLQGWQATFGGGDH PPKSDPMGHHHHHHGRRRASVAAGILVPRGSP GLDGIYARGIQMTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGA VPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLV LDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKE ELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASG SVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQ QKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKA SNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLV LVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLR ALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLV RSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNM MNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTC HSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRL VEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGH ALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASS QIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSA GFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISE SMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKV EDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGE ESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTS EEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGAT LAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQG TTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADS MLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTI QENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAY VHHQALLDVKNIAHQNKFGEDMPHPH
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分子量
161 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HDAC6 (Histone Deacetylase 6) is a member of the histone deacetylase family, which plays a vital role in various cellular processes, including gene expression regulation, protein degradation, and cellular stress responses. Unlike other HDACs, HDAC6 primarily resides in the cytoplasm and is known for its deacetylase activity on non-histone substrates, particularly affecting the dynamics of microtubules and the regulation of heat shock protein 90 (Hsp90). Its involvement in diverse biological processes has drawn significant attention, as aberrations in HDAC6 activity have been linked to various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. The ability of HDAC6 to regulate key cellular pathways makes it a promising therapeutic target, leading researchers to explore HDAC6 as a potential biomarker and drug target in personalized medicine. Consequently, the study of recombinant HDAC6 proteins has gained importance, facilitating the elucidation of the enzyme's structure, function, and interactions with pharmacological agents. Such research not only enhances our understanding of HDAC6's biological roles but also paves the way for developing HDAC6 inhibitors that could serve as effective therapeutic strategies against diseases characterized by dysregulated deacetylase activity. Given the rising interest in targeted therapies, further investigation into HDAC6's mechanisms and its role in disease etiology is essential for advancing therapeutic interventions.
