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Custom Protein Tag Service

Protein tags are essential tools for protein purification, detection, and functional research. Rational tag design can significantly improve experimental efficiency and result reliability. We provide professional custom protein tag services, flexibly designing and selecting the most suitable tagging strategies based on the structural characteristics of target proteins and downstream application requirements. Our service covers a wide range of conventional and functional tags, with customizable N-terminal and C-terminal tagging options. We fully balance purification efficiency, detection sensitivity, and the retention of protein biological activity. Through scientific tagging strategies and rigorous process control, the designed tags remain stable and do not interfere with the native conformation of target proteins. All delivered products undergo strict quality inspection, making them widely applicable in diverse experimental scenarios, including protein purification, immunodetection, fluorescence imaging, and molecular interaction analysis.

  • 1 Working Day

    Demand Assessment

    Clarify the protein type, application scenarios and specific functional requirements for tags.

  • 1 Working Day

    Tag Design

    Select suitable tag types, fusion methods and N-terminal / C-terminal positioning strategies.

  • 1 Week

    Construction & Expression

    Complete the construction of tagged proteins, followed by expression and preliminary preparation.

  • 1-2 Weeks

    Purification & Processing

    Conduct high-efficiency purification leveraging tag properties; tag cleavage is available if required.

  • 1-2 Working Day

    Quality Verification

    Verify protein purity, tag stability and functional retention.

  • 1个 Working Day

    Result Delivery

    Deliver customized tagged proteins together with relevant quality data.

Service Advantage

Click to Customize

  • Custom Protein Tag Service

    A variety of conventional and functional tags can be customized according to experimental objectives, including His-tag, FLAG-tag, Strep-tag, GST-tag, Fc-tag, and fluorescent tags such as GFP / mCherry, to meet diverse application demands in protein purification, detection, tracing and functional research.

  • Precise Design of Tag Position

    Customization of N-terminal and C-terminal tags is available. Rational design is carried out based on the structural and functional characteristics of target proteins to effectively minimize potential interference of tags with protein folding, bioactivity and molecular interactions.

  • Support for Tag Cleavage & Tag-Free Protein Preparation

    Specific cleavage sites including TEV, 3C and Thrombin can be inserted between the tag and target protein to enable tag removal after purification, yielding tag-free proteins that closely resemble native forms, which are suitable for functional research and structural analysis.

  • Optimized for Both Expression Level and Protein Bioactivity

    Combining the properties of target proteins and tag types, we systematically optimize the selection of expression systems (E. coli, yeast, insect cells, mammalian cells) and expression conditions to boost expression yields while maintaining favorable solubility and biological activity of proteins.

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Frequently Asked Questions

  • What types of protein tags can be customized?

    We support customization of various common and functional tags, including His, GST, Flag, HA, Myc, Strep, Fc, SUMO, MBP and more, which can be flexibly selected according to protein properties and experimental requirements.

  • Can tags be fused to the N-terminus or C-terminus?

    Customization at either the N-terminus or C-terminus is available. Prior to design, we conduct an evaluation based on protein structure, functional domains and downstream applications (e.g., activity assays, interaction analysis) to prevent impairment of protein bioactivity.

  • Will protein tags affect protein bioactivity?

    Properly designed tags generally have no impact on protein bioactivity. For activity-sensitive proteins, we can recommend small-molecule tags or provide cleavable tag solutions to maximally preserve the native conformation of target proteins.

  • Is tag cleavage service available?

    Yes. We support the design of common cleavage sites such as TEV, Thrombin and Factor Xa, and offer tag cleavage and post-cleavage purification services to obtain high-purity tag-free target proteins.

If you have any questions, please contact us.

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