Analytical Data
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基因名
HDAC2
- Application
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别名
HDAC2；Histone deacetylase 2
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种属
Human
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表达系统
E. coli
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标签
N-terminal His-Tag and GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92769
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表达区间
1-488aa
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氨基酸序列
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEI YRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLF EFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAIL ELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIG AGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD RLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCE IPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAP GVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGR RNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLS NP
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分子量
81.3kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
The study of HDAC2 (Histone Deacetylase 2) recombinant protein has gained significant attention due to its crucial role in various cellular processes, including gene expression regulation, cell differentiation, and apoptosis. HDAC2 is part of the histone deacetylase family, enzymes that remove acetyl groups from histones, leading to a compact chromatin structure and transcriptional repression. Dysregulation of HDAC2 has been implicated in several diseases, particularly cancer, neurodegenerative disorders, and cardiovascular diseases, making it a promising target for therapeutic intervention. Notably, HDAC2 has been associated with tumorigenesis, where its overexpression contributes to the silencing of tumor suppressor genes. The development of HDAC inhibitors has emerged as a potential strategy for reversing these effects and restoring normal gene expression. Furthermore, understanding the structure and function of recombinant HDAC2 can provide insights into its mechanisms of action and facilitate the design of specific inhibitors. Recent advances in protein engineering and purification techniques have enabled the production of functional recombinant HDAC2, allowing researchers to delve deeper into its biochemical properties and interactions with various substrates. This research is not only critical for elucidating HDAC2's role in health and disease but also for advancing the field of epigenetic therapies, highlighting the importance of this enzyme in potential clinical applications.
