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SPR Biomolecular Interaction Detection Service

Ipodix Biotech Inc. specializes in high-quality Surface Plasmon Resonance (SPR) detection services, backed by five years of professional technical expertise and a proprietary protein library of over 30,000 targets. Our service covers a comprehensive portfolio of biomolecular interaction analysis, including affinity profiling for protein‑drug, protein‑small molecule, protein‑protein, protein‑DNA, and protein‑polysaccharide binding systems. We also provide a full suite of customized experimental services, such as antibody screening and characterization, compound library screening, and ligand fishing assays based on SPR technology. Equipped with industry-leading Cytiva Biacore systems, including Biacore 1K+ and Biacore 8K+, our professional and experienced technical team delivers fully tailored SPR analytical solutions to meet diverse project requirements. We serve universities, hospitals, research institutions, and biopharmaceutical enterprises worldwide, enabling efficient, accurate, and reproducible biomolecular interaction analysis for your research and drug development programs.

Sample Types

  • Label-free

    • No fluorescent labeling required for samples • Preserves native binding conformation • Eliminates bias introduced by modification • More authentic and reliable data output

  • Real-time monitoring

    • Real-time recording of binding processes • Intuitive dynamic sensorgram visualization • Rapid assessment of binding affinity • Support process tracking & analysis

  • Full kinetic profiling

    • Output kon / koff kinetic constants • Calculate equilibrium dissociation constant KD • Distinguish binding strength and association/dissociation rates • Enable in-depth interaction mechanism analysis

  • High sensitivity & precision

    • Detectable even for weak binding signals • High affinity resolution • Excellent assay reproducibility • Ideal for high-precision characterization requirements

  • Broad sample compatibility

    • Compatible with diverse biomolecular interaction types • Assays available for proteins, antibodies and small molecules • Evaluation feasible for complex biological matrices • Highly flexible customized experimental workflows

  • Customized assay design

    • One-on-one custom experimental design • Multiple immobilization strategies available • Optimizable buffer systems • Improve assay success rate and data quality

Service Advantage

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  • Biacore 1K+

    Widely applied in kinetic characterization, affinity measurement, concentration and potency analysis, epitope identification, selectivity studies, single-concentration kinetic screening, small-molecule interaction profiling, fragment screening (library-wide screening, binding level screening, affinity screening), buffer condition screening, competitive binding assays, and multi-complex interaction analysis

  • Biacore™ 8K+

    As a new-generation high-sensitivity biomolecular interaction analysis platform, it delivers exceptional throughput and detection capacity, making it an indispensable tool for biopharmaceutical R&D. It supports acquisition of kinetic and affinity parameters (ka, kd, KD), specificity and selectivity data, screening datasets, epitope binning results, as well as concentration and relative potency measurements.

  • CM5/CM7 Sensor Chips

    CM5 Sensor Chip Applicable Samples: Wide coverage including protein-protein, protein-small molecule, protein-peptide, antibodies, capture kits, etc. CM7 Sensor Chip: Primarily used for protein-small molecule assays; higher carboxylation level enables greater ligand immobilization capacity.

  • Library of Over 30,000 Proteins

    Specialized in scalable manufacturing of high-quality recombinant proteins, the platform satisfies 99.9% protein quality specifications and provides flexible tailor-made customization services. All protein products are released at experimental-grade standards, compatible for direct loading onto SPR instruments. An end-to-end seamless workflow from protein production to functional characterization is established to expedite academic research and biopharmaceutical project progression.

More related services

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Frequently Asked Questions

  • Which buffer is generally selected for affinity analysis? What are the requirements for protein buffer systems?

    Common buffers adopted for affinity analysis are PBS and HBS. For NTA sensor chips, EDTA must not be present in running buffers. For CM5 sensor chips, the ligand protein buffer should be free of amine-containing substances such as Tris. The buffer formulation of target proteins shall be confirmed prior to procurement. Recombinant proteins are manufactured in strict compliance with SPR experimental specifications to match relevant assay buffer requirements.

  • What sample materials are required for SPR measurement?

    Only two molecules involved in the interaction need to be prepared. Taking protein-compound interaction as an example, only the target protein (50–100 μg) and compound (1–2 mg) are required. All other reagents and consumables including sensor chips will be provided. A library of over 30,000 recombinant proteins is available for selection to eliminate concerns over protein sample supply.

  • What is the typical lead time for SPR testing services?

    The standard turnaround time for SPR testing services is within one week upon sample arrival. If the target protein is available from our in-stock library and expedited processing is requested for special orders, experimental results can be delivered within 2 to 3 working days.

  • Will multiple concentration gradients be configured for small-molecule compounds in SPR assays?

    For assays involving compound samples, 5 concentration gradients will be adopted by default. Customized gradient series with additional concentrations can be arranged upon specific client requests.

If you have any questions, please contact us.

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IPODIX Biotech Inc

2108 N ST, STE N
Sacramento, CA 95816, USA

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