Analytical Data
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基因名
USP50
- Application
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别名
USP50; Inactive ubiquitin carboxyl-terminal hydrolase 50; Inactive ubiquitin-specific peptidase 50
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q70EL3
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表达区间
1-339 aa
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氨基酸序列
MTSQPSLPAD DFDIYHVLAE CTDYYDTLPV KEADGNQPHF QGVTGLWNLG NTCCVNAISQ CLCSILPLVE YFLTGKYITA LQKFLLPSDC SEVATAFAYL MTDMWLGDSD CVSPEIFWSA LGNLYPAFTK KMQQDAQEFL ICVLNELHEA LKKYHYSRRR SYEKGSTQRC CRKWITTETS IITQLFEEQL NYSIVCLKCE KCTYKNEVFT VFSLPIPSKY ECSLRDCLQC FFQQDALTWN NEIHCSFCET KQETAVRASI SKAPKIIIFH LKRFDIQGTT KRKLRTDIHY PLTNLDLTPY ICSIFRKYPK YNLCAVVNHF GDLDGGHYTA FCKNSVTQA
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分子量
38.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The USP50 protein, a member of the ubiquitin-specific protease (USP) family, has garnered significant attention in recent years due to its crucial role in regulating protein stability and cellular signaling pathways. Research indicates that USP50 is involved in various physiological processes, including cell cycle regulation, DNA damage response, and apoptosis, underscoring its importance in maintaining cellular homeostasis. Notably, alterations in the expression or activity of USP50 have been linked to several diseases, including cancer and neurodegenerative conditions, suggesting that it may serve as a potential therapeutic target. Advances in proteomic and genomic technologies have facilitated the detailed characterization of USP50, revealing its substrates and the mechanisms through which it exerts its effects. Additionally, the exploration of USP50 interactions within the ubiquitin-proteasome system provides insights into the broader implications of protein ubiquitination in health and disease. As the understanding of USP50 continues to evolve, it holds promise for the development of novel diagnostic and therapeutic strategies aimed at modulating its activity to restore normal cellular functions. Therefore, ongoing research into USP50 not only enhances our comprehension of fundamental biological processes but also potentially paves the way for innovative treatment options in various pathologies.
