Analytical Data
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Gene name
USP50
- Application
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Alternative Names
USP50; Inactive ubiquitin carboxyl-terminal hydrolase 50; Inactive ubiquitin-specific peptidase 50
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q70EL3
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Expression Region
1-339 aa
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AA Sequence
MTSQPSLPAD DFDIYHVLAE CTDYYDTLPV KEADGNQPHF QGVTGLWNLG NTCCVNAISQ CLCSILPLVE YFLTGKYITA LQKFLLPSDC SEVATAFAYL MTDMWLGDSD CVSPEIFWSA LGNLYPAFTK KMQQDAQEFL ICVLNELHEA LKKYHYSRRR SYEKGSTQRC CRKWITTETS IITQLFEEQL NYSIVCLKCE KCTYKNEVFT VFSLPIPSKY ECSLRDCLQC FFQQDALTWN NEIHCSFCET KQETAVRASI SKAPKIIIFH LKRFDIQGTT KRKLRTDIHY PLTNLDLTPY ICSIFRKYPK YNLCAVVNHF GDLDGGHYTA FCKNSVTQA
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Molecular Weight
38.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The USP50 protein, a member of the ubiquitin-specific protease (USP) family, has garnered significant attention in recent years due to its crucial role in regulating protein stability and cellular signaling pathways. Research indicates that USP50 is involved in various physiological processes, including cell cycle regulation, DNA damage response, and apoptosis, underscoring its importance in maintaining cellular homeostasis. Notably, alterations in the expression or activity of USP50 have been linked to several diseases, including cancer and neurodegenerative conditions, suggesting that it may serve as a potential therapeutic target. Advances in proteomic and genomic technologies have facilitated the detailed characterization of USP50, revealing its substrates and the mechanisms through which it exerts its effects. Additionally, the exploration of USP50 interactions within the ubiquitin-proteasome system provides insights into the broader implications of protein ubiquitination in health and disease. As the understanding of USP50 continues to evolve, it holds promise for the development of novel diagnostic and therapeutic strategies aimed at modulating its activity to restore normal cellular functions. Therefore, ongoing research into USP50 not only enhances our comprehension of fundamental biological processes but also potentially paves the way for innovative treatment options in various pathologies.
