Analytical Data
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Gene name
TMEM110
- Application
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Alternative Names
STIMATE; TMEM110; Store-operated calcium entry regulator STIMATE; STIM-activating enhancer encoded by TMEM110; Transmembrane Protein 110
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86TL2
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Expression Region
1-294 aa
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AA Sequence
MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPV
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Molecular Weight
59.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM110, a member of the transmembrane protein family, has garnered considerable interest in recent research due to its involvement in various cellular processes and potential implications in human diseases. Initially identified as a protein associated with membrane dynamics, TMEM110 has been linked to intracellular signaling pathways and cellular responses to external stimuli. Understanding its specific functions and mechanisms of action is crucial, as dysregulation of TMEM110 expression has been associated with conditions such as cancer and neurodegenerative disorders. The study of recombinant TMEM110 protein allows researchers to investigate its structure, function, and interactions at a molecular level. By producing this protein in a controlled laboratory setting, scientists can conduct assays to examine its role in cell signaling, membrane trafficking, and potential interactions with other biomolecules. This research is crucial for elucidating the biological significance of TMEM110 and for exploring its potential as a therapeutic target. Furthermore, the study of TMEM110 can also provide insights into the broader family of transmembrane proteins, enhancing our understanding of their contributions to cellular homeostasis and pathology. Overall, the recombinant expression of TMEM110 represents a promising avenue for delving deeper into the intricacies of cell biology and developing novel therapeutic strategies.
