Analytical Data
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Gene name
NR1H4
- Application
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Alternative Names
Farnesoid X-activated receptor;Farnesol receptor HRR-1;Nuclear receptor subfamily 1 group H member 4;Retinoid X receptor-interacting protein 14;RXR-interacting protein 14)
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Species
Mouse
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Source
E. coli
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Tag
N-his
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q60641
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Expression Region
1-488aa
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AA Sequence
MVMQFQGLENPIQISLHHSHRLSGFVPEGMSVKPAKGMLTEHAAGPLGQNLDLESYSPYNNVPFPQVQPQISSSSYYSNLGFYPQQPEDWYSPGIYELRRMPAETGYQGETEVSEMPVTKKPRMAAASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTANEDDSEGRDLRQVTSTTKFCREKTELTADQQTLLDYIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATSHVQILVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPAGHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKMYQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
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Molecular Weight
63 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
NR1H4, also known as Liver X Receptor alpha (LXRα), is a nuclear receptor that plays a crucial role in regulating lipid metabolism, inflammation, and glucose homeostasis. This protein has drawn considerable attention in recent years due to its involvement in a variety of metabolic diseases, including atherosclerosis, obesity, and diabetes. Research into NR1H4 has revealed that it functions as a transcription factor, activated by oxysterols, which are cholesterol derivatives that modulate the expression of genes involved in cholesterol efflux, fatty acid synthesis, and insulin sensitivity. The potential therapeutic implications of NR1H4 in cardiovascular diseases and insulin resistance have prompted investigations into its mechanism of action and interactions with other signaling pathways. Furthermore, studies have shown that NR1H4 influences the macrophage foam cell formation that leads to atherosclerosis, making it a target for drug development aimed at cardiovascular protection. Given the rising prevalence of metabolic disorders worldwide, NR1H4 continues to be a significant focus for researchers aiming to develop novel therapeutic strategies that leverage its regulatory functions in lipid and glucose metabolism, highlighting the importance of understanding its structure, function, and the potential for recombinant protein applications in drug design and metabolic disease treatment.
