Analytical Data
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基因名
E2F5
- Application
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别名
E2F 5; E2F transcription factor 5; E2F transcription factor 5 p130 binding; E2F-5; E2f5; E2F5_HUMAN; p130 binding; Transcription factor E2F5
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15329
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表达区间
1-346
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氨基酸序列
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSIKNVMDDSINNRFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQILNY
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分子量
64.46 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
E2F5 is a member of the E2F transcription factor family, which plays a crucial role in regulating the cell cycle and gene expression associated with cell proliferation. Research on E2F5 has gained prominence due to its implications in both normal developmental processes and various pathophysiological conditions, especially cancer. Unlike other E2F members, E2F5 has been shown to act predominantly as a transcriptional repressor, which adds complexity to its function in tumorigenesis and cell cycle regulation. Studies indicate that E2F5 can interact with other proteins to modulate its activity, influencing cellular responses to growth signals and stress. Understanding the mechanisms underlying E2F5 function, including its regulatory pathways and interaction networks, is pivotal for elucidating its role in cancer and developing potential therapeutic strategies. Furthermore, the investigation of E2F5 in different cellular contexts may reveal its contributions to developmental processes and cellular differentiation. As research progresses, E2F5 is emerging as a significant factor in understanding the intricate balance of cell cycle regulation and its associated disorders, highlighting the need for continued exploration to fully uncover its biological significance and potential as a target for targeted therapies.
