Analytical Data
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Gene name
DSCR3
- Application
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Alternative Names
VPS26C; DCRA; DSCR3; DSCRA; Vacuolar protein sorting-associated protein 26C; Down syndrome critical region protein 3; Down syndrome critical region protein A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14972
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Expression Region
1-297aa
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AA Sequence
MGTALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHSAPQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVVLLHPDHLITENFPLKLCRI
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Molecular Weight
59.07 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DSCR3, or Down Syndrome Critical Region 3, is a gene located on chromosome 21 and is part of the region implicated in Down syndrome. The study of DSCR3 has gained significance due to its association with various cellular processes, including apoptosis, stress response, and neuronal development. Research indicates that DSCR3 may play a role in regulating gene expression and cellular signaling pathways, potentially contributing to the dysregulated physiology observed in individuals with Down syndrome. Furthermore, DSCR3 has been identified as a suppressor of tumor growth, suggesting its involvement in oncological research. Given that individuals with Down syndrome exhibit a higher incidence of certain cancers, exploring the functional attributes of DSCR3 might reveal insights into both the developmental challenges associated with the syndrome and possible therapeutic avenues for cancer treatment. Investigating the molecular mechanisms underlying DSCR3's actions could enhance our understanding of its role in health and disease, as well as its potential as a biomarker or target for therapeutic interventions. The growing interest in DSCR3 reflects its significance not only in the context of Down syndrome but also in broader biological and medical frameworks.
