Analytical Data
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Gene name
SPRY2
- Application
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Alternative Names
SPRY2；Protein sprouty homolog 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43597
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Expression Region
1-315aa
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AA Sequence
MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
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Molecular Weight
42.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPRY2 (Sprouty Protein 2) is a member of the Sprouty family of proteins, known for their role as inhibitors of receptor tyrosine kinase signaling pathways, which are crucial in various physiological processes including cell proliferation, differentiation, and survival. Elevated SPRY2 expression has been implicated in numerous cancers, making it a potential target for therapeutic intervention. The study of SPRY2 recombinant protein is essential for understanding its biological function and molecular mechanisms. By expressing and purifying SPRY2 in a recombinant form, researchers can explore its interactions with other proteins, characterize its enzymatic activity, and elucidate its role in modulating signaling pathways, particularly in the context of oncogenesis. Furthermore, SPRY2's regulatory function in the cellular response to growth factors such as fibroblast growth factor (FGF) and epidermal growth factor (EGF) makes it a significant player in developmental biology and tumor progression. Investigating SPRY2 in recombinant form allows for the development of specific inhibitors or modulators, which could provide novel therapeutic strategies for cancer treatment. Moreover, studying SPRY2 could lead to insights into its potential as a biomarker for cancer diagnosis and prognosis, highlighting its relevance in both fundamental research and clinical applications. The ongoing exploration of SPRY2 through recombinant technology holds promise for advancing our understanding of its complex roles in health and disease.
