Analytical Data
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基因名
SPRY3
- Application
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别名
SPRY3；Protein sprouty homolog 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43610
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表达区间
1-288aa
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氨基酸序列
MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK SDWSLATMPT SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL ASITPSPSGQ SIIRTQPGAG VHPKADGALK GEAEQSAGHP SEHLFICEEC GRCKCVPCTA ARPLPSCWLC NQRCLCSAES LLDYGTCLCC VKGLFYHCST DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP TRGCLHLCQQ GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPRY3, or Sprouty homolog 3, is a member of the Sprouty protein family, which plays a critical role in modulating signaling pathways, notably those involving receptor tyrosine kinases and the RAS-mitogen-activated protein kinase (MAPK) cascade. Research indicates that SPRY3 functions as a negative regulator of these pathways, thereby influencing cellular processes such as proliferation, differentiation, and survival. Given its significant involvement in cancer biology and various developmental processes, SPRY3 has emerged as a target of interest in therapeutic research. Its expression patterns are often altered in tumors, suggesting a potential role in tumorigenesis and cancer progression. The study of SPRY3 recombinant proteins offers insights into its functional mechanisms and interactions at the molecular level, facilitating the understanding of its contributions to cellular signaling. Additionally, investigating SPRY3 in the context of specific diseases could lead to novel diagnostic and therapeutic strategies. As the interaction of SPRY3 with other signaling molecules is complex and context-dependent, the generation of SPRY3 recombinant proteins allows for the exploration of its biophysical properties, interaction dynamics, and regulatory functions, providing a platform to decipher its role in both normal biology and pathological conditions.
