Analytical Data
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Gene name
DSCR2
- Application
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Alternative Names
PSMG1; C21LRP; DSCR2; PAC1; Proteasome assembly chaperone 1; PAC-1; Chromosome 21 leucine-rich protein; C21-LRP; Down syndrome critical region protein 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95456
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Expression Region
1-288aa
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AA Sequence
MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEVSLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSESTGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT
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Molecular Weight
57.42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DSCR2 (Down Syndrome Candidate Region 2) is a gene located in the Down syndrome critical region on chromosome 21, which has garnered attention due to its potential implications in developmental processes and various pathologies. Research has shown that DSCR2 plays a crucial role in regulating cellular functions, including apoptosis, cell proliferation, and stress responses, making it a candidate for further investigation in the context of Down syndrome and other diseases. The protein encoded by DSCR2 is believed to be involved in the modulation of inflammatory responses and has been linked to disorders such as Alzheimer's disease and cancer. Understanding the molecular mechanisms of DSCR2 may provide insights into the pathophysiology of these conditions. Recent studies have focused on its structural properties and functional domains, which could elucidate its role in cellular signaling pathways. Additionally, the exploration of DSCR2's interactions with other proteins and its potential as a therapeutic target is of significant interest in the quest to develop novel interventions for related diseases. Given its multifaceted roles in health and disease, the study of DSCR2 protein is pivotal in advancing our knowledge of genetic regulation and its broader implications on human health.
