Analytical Data
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基因名
DSCR1L2
- Application
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别名
RCAN3; DSCR1L2; Calcipressin-3; Down syndrome candidate region 1-like protein 2; Myocyte-enriched calcineurin-interacting protein 3; MCIP3; Regulator of calcineurin 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKA8
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表达区间
1-241aa
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氨基酸序列
MLRDTMKSWNDSQSDLCSTDQEEEEEMIFGENEGDLDEMMDLSDLPTSLFACSVHEAVFEAREQKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQKLKLYFAQVQMSGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETKNPKQKIAQTRRPDPPTAALNEPQTFDCAL
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分子量
52.25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DSCR1L2 (Down syndrome critical region 1-like protein 2) is a member of the DSCR family, which is implicated in several crucial biological processes, including neurodevelopment and cellular response to stress. Research surrounding DSCR1L2 has gained traction due to its potential involvement in Down syndrome and its implications in neurodegenerative diseases, such as Alzheimer's. The protein is thought to play a role in the regulation of gene expression and protection against apoptosis, thereby influencing neuronal survival and function. Its expression pattern further suggests a critical role in the central nervous system, particularly during development and in response to cellular injury. Recent studies have indicated that DSCR1L2 may interact with various signaling pathways and molecular partners, highlighting its significance in maintaining cellular homeostasis. Understanding the molecular mechanisms and pathways that DSCR1L2 engages in could provide insights into its contributions to neurodevelopmental disorders and potential therapeutic targets for conditions associated with dysregulated cell survival. The ongoing investigation into the biological roles and regulatory mechanisms of DSCR1L2 represents an essential step in deciphering the complexities of neurobiology and may pave the way for novel interventions in related pathologies.
