Analytical Data
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基因名
DSCR10
- Application
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别名
DSCR10Down syndrome critical region protein 10
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P59022
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表达区间
1-87aa
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氨基酸序列
MQIVQGFPAD APLCALMWTC SFLLPGLQTE TPYPCTSLCL SSSQSAHPPL PVRVFSAESG YGIPFCAEPC SRVTVCHLQA VPVCMPV
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分子量
9.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The DSCR10 protein, a member of the Down syndrome critical region 10, has garnered attention in the fields of molecular biology and genetics due to its potential roles in various cellular processes and its association with Down syndrome. This protein is situated within a chromosomal region that is critically implicated in the phenotypic manifestations of Down syndrome, a condition caused by trisomy of chromosome 21. Initially identified for its involvement in the regulation of genes related to development and neurogenesis, DSCR10 has subsequently been linked to several cellular functions, including apoptosis, cell cycle regulation, and response to stress. Research has highlighted its role as a modulator of signaling pathways, particularly in the context of neurodegenerative diseases, where its expression levels may influence neuronal survival and differentiation. Given that a substantial portion of individuals with Down syndrome display varying degrees of cognitive impairment and increased susceptibility to Alzheimer’s disease, understanding the mechanisms by which DSCR10 operates could provide insights into potential therapeutic strategies. Moreover, studies have indicated that altered expression of DSCR10 is observed in various malignancies, suggesting a broader implication for this protein beyond developmental disorders. As such, ongoing research aims to elucidate the precise molecular functions of DSCR10, its interactions within cellular networks, and its potential as a biomarker or therapeutic target, thereby contributing to a deeper understanding of both Down syndrome and other related health conditions.
