Analytical Data
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Gene name
DSCR10
- Application
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Alternative Names
DSCR10Down syndrome critical region protein 10
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P59022
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Expression Region
1-87aa
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AA Sequence
MQIVQGFPAD APLCALMWTC SFLLPGLQTE TPYPCTSLCL SSSQSAHPPL PVRVFSAESG YGIPFCAEPC SRVTVCHLQA VPVCMPV
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Molecular Weight
9.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The DSCR10 protein, a member of the Down syndrome critical region 10, has garnered attention in the fields of molecular biology and genetics due to its potential roles in various cellular processes and its association with Down syndrome. This protein is situated within a chromosomal region that is critically implicated in the phenotypic manifestations of Down syndrome, a condition caused by trisomy of chromosome 21. Initially identified for its involvement in the regulation of genes related to development and neurogenesis, DSCR10 has subsequently been linked to several cellular functions, including apoptosis, cell cycle regulation, and response to stress. Research has highlighted its role as a modulator of signaling pathways, particularly in the context of neurodegenerative diseases, where its expression levels may influence neuronal survival and differentiation. Given that a substantial portion of individuals with Down syndrome display varying degrees of cognitive impairment and increased susceptibility to Alzheimer’s disease, understanding the mechanisms by which DSCR10 operates could provide insights into potential therapeutic strategies. Moreover, studies have indicated that altered expression of DSCR10 is observed in various malignancies, suggesting a broader implication for this protein beyond developmental disorders. As such, ongoing research aims to elucidate the precise molecular functions of DSCR10, its interactions within cellular networks, and its potential as a biomarker or therapeutic target, thereby contributing to a deeper understanding of both Down syndrome and other related health conditions.
