Analytical Data
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Gene name
DSCAM
- Application
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Alternative Names
CHD2 42; CHD2 52; CHD2; Down syndrome cell adhesion molecule; DSCAM; DSCAM_HUMAN; human CHD2-52 down syndrome cell adhesion molecule 2; 9; OTTHUMP00000109193 2; SD11109p
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60469
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Expression Region
1922-2008aa
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AA Sequence
SEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDP
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Molecular Weight
35.31 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DSCAM (Down syndrome cell adhesion molecule) is a gene that plays a critical role in the development of the nervous system, particularly in the formation and function of neural circuits. It is known for its extensive alternative splicing, producing over 38,000 different isoforms, which allows for a diverse range of functions in neuronal recognition and connectivity. Research into DSCAM has gained significant attention due to its implications in neurodevelopmental disorders, including Down syndrome and autism, where dysregulation of DSCAM expression may contribute to cognitive and behavioral abnormalities. Recombining DSCAM proteins through genetic engineering techniques has opened new avenues for studying their specific roles and interactions within the neural architecture. By producing recombined DSCAM proteins in various model systems, researchers aim to elucidate the molecular mechanisms underlying its function in neuronal cell adhesion and synaptic plasticity. This research not only enhances our understanding of normal brain development but also helps identify potential therapeutic targets for treating related disorders. The study of DSCAM recombined proteins thus stands at the intersection of molecular biology, neuroscience, and clinical research, reflecting its importance in addressing complex neurodevelopmental challenges.
