Analytical Data
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基因名
DSCAM
- Application
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别名
CHD2 42; CHD2 52; CHD2; Down syndrome cell adhesion molecule; DSCAM; DSCAM_HUMAN; human CHD2-52 down syndrome cell adhesion molecule 2; 9; OTTHUMP00000109193 2; SD11109p
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60469
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表达区间
1922-2008aa
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氨基酸序列
SEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDP
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分子量
35.31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DSCAM (Down syndrome cell adhesion molecule) is a gene that plays a critical role in the development of the nervous system, particularly in the formation and function of neural circuits. It is known for its extensive alternative splicing, producing over 38,000 different isoforms, which allows for a diverse range of functions in neuronal recognition and connectivity. Research into DSCAM has gained significant attention due to its implications in neurodevelopmental disorders, including Down syndrome and autism, where dysregulation of DSCAM expression may contribute to cognitive and behavioral abnormalities. Recombining DSCAM proteins through genetic engineering techniques has opened new avenues for studying their specific roles and interactions within the neural architecture. By producing recombined DSCAM proteins in various model systems, researchers aim to elucidate the molecular mechanisms underlying its function in neuronal cell adhesion and synaptic plasticity. This research not only enhances our understanding of normal brain development but also helps identify potential therapeutic targets for treating related disorders. The study of DSCAM recombined proteins thus stands at the intersection of molecular biology, neuroscience, and clinical research, reflecting its importance in addressing complex neurodevelopmental challenges.
