Analytical Data
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Gene name
DNTTIP2
- Application
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Alternative Names
DNTTIP2; ERBP; TDIF2Deoxynucleotidyltransferase terminal-interacting protein 2; Estrogen receptor-binding protein; LPTS-interacting protein 2; LPTS-RP2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5QJE6
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Expression Region
1-756aa
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AA Sequence
MVVTRSARAKASIQAASAESSGQKSFAANGIQAHPESSTGSDARTTAESQTTGKQSLIPRTPKARKRKSRTTGSLPKGTEPSTDGETSEAESNYSVSEHHDTILRVTRRRQILIACSPVSSVRKKPKVTPTKESYTEEIVSEAESHVSGISRIVLPTEKTTGARRSKAKSLTDPSQESHTEAISDAETSSSDISFSGIATRRTRSMQRKLKAQTEKKDSKIVPGNEKQIVGTPVNSEDSDTRQTSHLQARSLSEINKPNFYNNDFDDDFSHRSSENILTVHEQANVESLKETKQNCKDLDEDANGITDDGKEINEKSSQLKNLSELQDTSLQQLVSQRHSTPQNKNAVSVHSNLNSEAVMKSLTQTFATVEVGRWNNNKKSPIKASDLTKFGDCGGSDDEEESTVISVSEDMNSEGNVDFECDTKLYTSAPNTSQGKDNSVLLVLSSDESQQSENSENEEDTLCFVENSGQRESLSGDTGSLSCDNALFVIDTTPGMSADKNFYLEEEDKASEVAIEEEKEEEEDEKSEEDSSDHDENEDEFSDEEDFLNSTKAKLLKLTSSSIDPGLSIKQLGGLYINFNADKLQSNKRTLTQIKEKKKNELLQKAVITPDFEKNHCVPPYSESKYQLQKKRRKERQKTAGDGWFGMKAPEMTNELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRIPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN
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Molecular Weight
83.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DNTTIP2 (DNA repair/tumor suppressor protein Tip60) is a member of the TIP60 family of proteins that play crucial roles in various cellular processes, including DNA damage repair, gene regulation, and apoptosis. Research has highlighted its importance in maintaining genomic stability and its potential involvement in cancer biology. Mutations or dysregulation of DNTTIP2 have been associated with multiple cancers, making it a significant target for therapeutic interventions. The protein acts as a histone acetyltransferase, influencing chromatin structure and accessibility, thereby modulating gene expression linked to cell cycle regulation and DNA repair mechanisms. Studies have shown that DNTTIP2 is involved in the cellular response to DNA double-strand breaks, facilitating repair pathways such as homologous recombination. Understanding the structure, function, and regulation of DNTTIP2 through recombinant protein studies can provide insights into its role in tumor suppression and its potential as a biomarker or target for cancer treatment. Given its multifaceted roles, the purification and characterization of DNTTIP2 as a recombinant protein hold promise for elucidating its biological functions and developing targeted therapies in oncology. The ongoing research into DNTTIP2 aims to uncover its mechanisms of action and its interactions with other proteins involved in DNA repair and cell survival pathways, paving the way for novel cancer treatment strategies.
