Analytical Data
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基因名
DNTTIP2
- Application
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别名
DNTTIP2; ERBP; TDIF2Deoxynucleotidyltransferase terminal-interacting protein 2; Estrogen receptor-binding protein; LPTS-interacting protein 2; LPTS-RP2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5QJE6
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表达区间
1-756aa
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氨基酸序列
MVVTRSARAKASIQAASAESSGQKSFAANGIQAHPESSTGSDARTTAESQTTGKQSLIPRTPKARKRKSRTTGSLPKGTEPSTDGETSEAESNYSVSEHHDTILRVTRRRQILIACSPVSSVRKKPKVTPTKESYTEEIVSEAESHVSGISRIVLPTEKTTGARRSKAKSLTDPSQESHTEAISDAETSSSDISFSGIATRRTRSMQRKLKAQTEKKDSKIVPGNEKQIVGTPVNSEDSDTRQTSHLQARSLSEINKPNFYNNDFDDDFSHRSSENILTVHEQANVESLKETKQNCKDLDEDANGITDDGKEINEKSSQLKNLSELQDTSLQQLVSQRHSTPQNKNAVSVHSNLNSEAVMKSLTQTFATVEVGRWNNNKKSPIKASDLTKFGDCGGSDDEEESTVISVSEDMNSEGNVDFECDTKLYTSAPNTSQGKDNSVLLVLSSDESQQSENSENEEDTLCFVENSGQRESLSGDTGSLSCDNALFVIDTTPGMSADKNFYLEEEDKASEVAIEEEKEEEEDEKSEEDSSDHDENEDEFSDEEDFLNSTKAKLLKLTSSSIDPGLSIKQLGGLYINFNADKLQSNKRTLTQIKEKKKNELLQKAVITPDFEKNHCVPPYSESKYQLQKKRRKERQKTAGDGWFGMKAPEMTNELKNDLKALKMRASMDPKRFYKKNDRDGFPKYFQIGTIVDNPADFYHSRIPKKQRKRTIVEELLADSEFRRYNRRKYSEIMAEKAANAAGKKFRKKKKFRN
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分子量
83.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNTTIP2 (DNA repair/tumor suppressor protein Tip60) is a member of the TIP60 family of proteins that play crucial roles in various cellular processes, including DNA damage repair, gene regulation, and apoptosis. Research has highlighted its importance in maintaining genomic stability and its potential involvement in cancer biology. Mutations or dysregulation of DNTTIP2 have been associated with multiple cancers, making it a significant target for therapeutic interventions. The protein acts as a histone acetyltransferase, influencing chromatin structure and accessibility, thereby modulating gene expression linked to cell cycle regulation and DNA repair mechanisms. Studies have shown that DNTTIP2 is involved in the cellular response to DNA double-strand breaks, facilitating repair pathways such as homologous recombination. Understanding the structure, function, and regulation of DNTTIP2 through recombinant protein studies can provide insights into its role in tumor suppression and its potential as a biomarker or target for cancer treatment. Given its multifaceted roles, the purification and characterization of DNTTIP2 as a recombinant protein hold promise for elucidating its biological functions and developing targeted therapies in oncology. The ongoing research into DNTTIP2 aims to uncover its mechanisms of action and its interactions with other proteins involved in DNA repair and cell survival pathways, paving the way for novel cancer treatment strategies.
