Analytical Data
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基因名
SLC13A5
- Application
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别名
Na(+)/citrate cotransporter; NaC2/NaCT; NaCT; Novel solute carrier family 13 (sodium dependent dicarboxylate transporter) (Slc13a2 or 3) member; S13A5_HUMAN; Slc13a5; Sodium coupled citrate transporter; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter; Solute carrier family 13 (sodium dependent citrate transporter); member 5; Solute carrier family 13 member 5
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86YT5
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表达区间
152-206 aa
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氨基酸序列
VEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCK
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分子量
31.79 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC13A5 is a member of the SLC (solute carrier) family of transporters, primarily known for its role in sodium-dependent citrate transport. Its significance has been underscored by its association with metabolic disorders, particularly its involvement in the regulation of cellular metabolism and energy homeostasis. Mutations in the SLC13A5 gene have been linked to a rare form of epilepsy known as early infantile epileptic encephalopathy (EIEE25), highlighting the protein's crucial role in neurological function. The study of recombinant SLC13A5 protein is essential for understanding its structure-function relationship and facilitating the development of therapeutic strategies for associated conditions. By producing this protein in a recombinant system, researchers can explore its transport mechanisms, interactions with other cellular components, and the impact of specific mutations on its function. Additionally, characterizing SLC13A5 at the molecular level can lead to insights into its regulatory pathways, which may reveal novel targets for pharmacological intervention. Overall, the investigation of SLC13A5 recombinant protein plays a pivotal role in elucidating its biological functions and potential as a target for treating metabolic and neurological disorders.
