Analytical Data
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Gene name
SLC13A3
- Application
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Alternative Names
dicarboxylate cotransporter 3; H sapiens mRNA for hepatocyte nuclear factor 4 gamma; hNaDC3; Na; Na(+)/dicarboxylate cotransporter 3; NaDC 3; NaDC-3; NADC3; S13A3_HUMAN; SDCT 2; SDCT2; SLC13A3; Sodium dependent high affinity dicarboxylate transporter 2; Sodium dependent high affinity dicarboxylate transporter 3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 (sodium dependent dicarboxylate transporter); member 3; Solute carrier family 13 member 3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WWT9
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Expression Region
1-602 aa
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AA Sequence
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL
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Molecular Weight
93.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC13A3, a member of the solute carrier family, encodes a sodium-dependent citrate transporter primarily expressed in the kidneys. It plays a crucial role in the reabsorption of citrate, influencing systemic citrate levels and, consequently, metabolic processes. Research has highlighted SLC13A3’s significance in various physiological conditions, such as metabolic disorders, kidney function, and urinary citrate excretion, which is pivotal for preventing calcium stone formation. Furthermore, dysregulation of SLC13A3 has been implicated in several pathophysiological conditions, including hypercitraturia and certain forms of renal osteodystrophy. The study of SLC13A3 recombinant protein has garnered attention in recent years due to its potential therapeutic implications. Investigating its structural and functional characteristics can provide insights into its transport mechanisms and interactions with other molecules in cellular metabolism. Additionally, understanding its regulatory pathways may unearth novel strategies for treating metabolic dysfunctions, making SLC13A3 a significant subject of contemporary biomedical research. This progress emphasizes the importance of elucidating the protein’s role in health and disease, thereby contributing to advancements in renal and metabolic health treatments.
