Analytical Data
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基因名
SCN8A
- Application
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别名
CerIII; CIAT; EIEE13; hNa6/Scn8a voltage gated sodium channel; MED; Motor endplate disease; NaCh 6; NaCh6; Nav 1.6; Nbna1; peripheral nerve protein type 4; PN 4; PN4; SCN8A; SCN8A_HUMAN; Sodium channel protein type 8 alpha subunit; Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII alpha subunit; Sodium channel protein type VIII subunit alpha; Sodium channel voltage gated type VIII alpha; Sodium channel voltage gated type VIII alpha polypeptide; Sodium channel voltage gated type VIII alpha subunit; Voltage gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UQD0
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表达区间
1854-1951 aa
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氨基酸序列
RVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVT
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分子量
36.52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCN8A, a gene encoding a voltage-gated sodium channel (NaV1.6), plays a critical role in the generation and propagation of action potentials in neurons. Mutations in SCN8A have been linked to various neurological disorders, including epilepsy, developmental delay, and movement disorders, highlighting its significance in neuronal excitability and function. The study of SCN8A recombinant protein is crucial for understanding the molecular mechanisms underlying these disorders. Researchers aim to elucidate how specific mutations affect channel properties like ion permeability, gating kinetics, and pharmacological responses. By expressing and purifying the SCN8A protein, scientists can employ biochemical and electrophysiological techniques to investigate its functional characteristics. This research not only provides insights into the pathophysiology of SCN8A-related diseases but also aids in the development of targeted therapies. Understanding the structure-function relationship of SCN8A may lead to novel treatment strategies for patients suffering from SCN8A-related disorders, emphasizing the importance of detailed studies on its recombinant protein.
