Analytical Data
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Gene name
DHRS2
- Application
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Alternative Names
DHRS2；SDR25C1；Dehydrogenase/reductase SDR family member 2. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13268
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Expression Region
1-300aa
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AA Sequence
MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRTSRNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPGPGA
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Molecular Weight
58.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DHRS2 (Dehydrogenase/Reductase 2) is a member of the short-chain dehydrogenase/reductase (SDR) family, primarily associated with cellular metabolic processes, including the metabolism of steroids and retinoids. Its pivotal role in the cellular response to oxidative stress and its involvement in various disease states, such as cancer and metabolic disorders, have garnered significant attention. Research indicates that DHRS2 is crucial for maintaining cellular homeostasis by regulating the levels of reactive oxygen species and participating in the detoxification of aldehydes. Additionally, this enzyme is implicated in the biosynthesis of key hormones and signaling molecules, which further underscores its biological importance. Investigations into DHRS2's structure-function relationships have highlighted its potential as a therapeutic target, particularly in the context of diseases characterized by metabolic dysregulation. Recent advancements in recombinant protein technology have enabled the production of DHRS2 in heterologous systems, facilitating detailed biochemical and structural analyses. These studies aim to elucidate the enzymatic mechanisms of DHRS2 and its interactions with various substrates, thereby providing insights into its functional significance in health and disease. As the understanding of DHRS2 expands, it is anticipated that this knowledge will pave the way for novel therapeutic strategies leveraging the enzyme's unique properties.
