Analytical Data
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Gene name
TLR3
- Application
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Alternative Names
TLR3；Toll-like receptor 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15455
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Expression Region
23-704aa
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AA Sequence
SSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT RYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFC TNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLEN LQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGR LFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLK WTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLF NVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKS NMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKI ESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLT RNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANIN DDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESN GFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI TSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELS SHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELLEHHHHHH
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Molecular Weight
79 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Toll-like receptor 3 (TLR3) is a critical component of the innate immune system that recognizes double-stranded RNA (dsRNA), a hallmark of viral infections, thereby initiating an immune response. Its role in detecting viral pathogens and activating downstream signaling pathways makes TLR3 a significant target for research in immunology and therapeutic development. The ability to produce recombinant TLR3 proteins has opened new avenues for studying its structure, function, and interaction with various ligands, including viral components and synthetic agonists. Understanding the signaling mechanisms activated by TLR3 can lead to insights into immune regulation and the development of vaccines and antiviral therapies. Moreover, exploring TLR3's role in various diseases, such as autoimmune disorders and cancer, emphasizes the importance of this receptor in both protective and pathological immune responses. Advances in recombinant protein technology have facilitated the generation of functional TLR3, which can be used in in vitro and in vivo studies to better characterize its activity and potential as a therapeutic target. Research on TLR3 is essential for elucidating its contributions to immune responses and developing novel immunomodulatory strategies.
