Analytical Data
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Gene name
CRX
- Application
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Alternative Names
CRX；CORD2；Cone-rod homeobox Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43186
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Expression Region
1-299aa
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AA Sequence
MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQ LEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQ QKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPS GSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASA FCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSP TSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL
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Molecular Weight
59 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CRX, or Cone-Rod Homeobox, is a transcription factor essential for the development and functioning of retinal photoreceptor cells, specifically cones and rods. Mutations in the CRX gene are associated with various inherited retinal diseases, leading to vision loss and impairments. Given the critical role of CRX in retinal health, researchers have focused on understanding its molecular mechanisms and pathways. The study of CRX recombinant proteins has gained importance due to its potential applications in gene therapy and regenerative medicine. By producing and characterizing CRX recombinant proteins, scientists aim to elucidate the protein's structure-function relationships, interactions with other molecular partners, and its regulatory role in gene expression within photoreceptors. This knowledge may pave the way for novel therapeutic strategies to restore vision or slow the progression of retinal degenerative conditions. Furthermore, CRX's involvement in the signaling pathways that govern photoreceptor differentiation and functionality underscores its significance in both basic research and clinical applications. The development of CRX-based therapies holds promise for patients suffering from CRX-related retinal disorders, representing a potential avenue for innovative treatments aimed at preserving or restoring sight.
