Analytical Data
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基因名
XAF1
- Application
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别名
XAF1；BIRC4BP；XIAP-associated factor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6GPH4
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表达区间
1-125aa
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氨基酸序列
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEGD FSVCRNCKRH VVSANFTLHE AYCLRFLVLC PECEEPVPKE TMEEHCKLEH QQVGCTMCQQ SMQKSSLEFH KANECQERPV ECKFCKLDMQ LSKLELHESY CGSRTELCQG CGQFIMHRML A
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XAF1 (X-linked inhibitor of apoptosis protein-associated factor 1) is a protein that plays a crucial role in the regulation of apoptosis and cellular stress responses. It was first identified as a protein that can bind to and inhibit the X-linked inhibitor of apoptosis protein (XIAP), which is known for its ability to prevent apoptosis by inhibiting caspases, the key executors of programmed cell death. The imbalance between pro-apoptotic and anti-apoptotic factors can lead to various diseases, including cancer, making XAF1 a significant focus in cancer research. Additionally, studies have indicated that XAF1 can sensitize cancer cells to chemotherapeutic agents, highlighting its potential as a therapeutic target. Furthermore, XAF1's role in enhancing the immune response against tumors suggests a broader relevance in immunotherapy. The recombinant production of XAF1 provides an invaluable tool for studies aimed at elucidating its mechanistic pathways and exploring its potential for therapeutic applications. Researchers are increasingly interested in understanding how modifications in XAF1 expression and function contribute to tumorigenesis and treatment resistance, thus establishing a foundation for future investigations into its role as both a biomarker for cancer prognosis and a target for innovative treatment strategies.
