Analytical Data
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基因名
PHF19
- Application
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别名
PHF19; PCL3; PHD finger protein 19; Polycomb-like protein 3; hPCL3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T6S3
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表达区间
1-580 aa
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氨基酸序列
MENRALDPGT RDSYGATSHL PNKGALAKVK NNFKDLMSKL TEGQYVLCRW TDGLYYLGKI KRVSSSKQSC LVTFEDNSKY WVLWKDIQHA GVPGEEPKCN ICLGKTSGPL NEILICGKCG LGYHQQCHIP IAGSADQPLL TPWFCRRCIF ALAVRKGGAL KKGAIARTLQ AVKMVLSYQP EELEWDSPHR TNQQQCYCYC GGPGEWYLRM LQCYRCRQWF HEACTQCLNE PMMFGDRFYL FFCSVCNQGP EYIERLPLRW VDVVHLALYN LGVQSKKKYF DFEEILAFVN HHWELLQLGK LTSTPVTDRG PHLLNALNSY KSRFLCGKEI KKKKCIFRLR IRVPPNPPGK LLPDKGLLPN ENSASSELRK RGKSKPGLLP HEFQQQKRRV YRRKRSKFLL EDAIPSSDFT SAWSTNHHLA SIFDFTLDEI QSLKSASSGQ TFFSDVDSTD AASTSGSAST SLSYDSRWTV GSRKRKLAAK AYMPLRAKRW AAELDGRCPS DSSAEGASVP ERPDEGIDSH TFESISEDDS SLSHLKSSIT NYFGAAGRLA CGEKYQVLAR RVTPEGKVQY LVEWEGTTPY
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分子量
65.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PHF19, also known as PHD-finger protein 19, is a member of the PHD-finger family of proteins, which are characterized by their ability to interact with chromatin and play critical roles in the regulation of gene expression. Recent studies have highlighted the importance of PHF19 in various biological processes, including development, cellular differentiation, and cancer progression. Its overexpression has been linked to aggressive forms of several cancers, making it a potential target for therapeutic interventions. Researchers have focused on characterizing PHF19's structure and function, particularly its role in the epigenetic regulation of transcription by interacting with other chromatin-modifying proteins. The recombinant form of PHF19 allows for detailed investigations into its molecular mechanisms, facilitating the understanding of its contributions to tumorigenesis and the potential for developing inhibitors that could disrupt its function. Furthermore, the study of PHF19 could provide insights into the broader context of PHD-finger proteins in cellular signaling pathways and their implications in disease states. As such, the research surrounding PHF19 is not only significant for cancer biology but also holds promise for advancing the development of innovative cancer therapies.
