Analytical Data
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基因名
OTUD1
- Application
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别名
OTUD1；DUBA7；OTDC1；OTU domain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5VV17
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表达区间
1-481aa
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氨基酸序列
MQLYSSVCTH YPAGAPGPTA AAPAPPAAAT PFKVSLQPPG AAGAAPEPET GECQPAAAAE HREAAAVPAA KMPAFSSCFE VVSGAAAPAS AAAGPPGASC KPPLPPHYTS TAQITVRALG ADRLLLHGPD PVPGAAGSAA APRGRCLLLA PAPAAPVPPR RGSSAWLLEE LLRPDCPEPA GLDATREGPD RNFRLSEHRQ ALAAAKHRGP AATPGSPDPG PGPWGEEHLA ERGPRGWERG GDRCDAPGGD AARRPDPEAE APPAGSIEAA PSSAAEPVIV SRSDPRDEKL ALYLAEVEKQ DKYLRQRNKY RFHIIPDGNC LYRAVSKTVY GDQSLHRELR EQTVHYIADH LDHFSPLIEG DVGEFIIAAA QDGAWAGYPE LLAMGQMLNV NIHLTTGGRL ESPTVSTMIH YLGPEDSLRP SIWLSWLSNG HYDAVFDHSY PNPEYDNWCK QTQVQRKRDE ELAKSMAISL SKMYIEQNAC S
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分子量
51 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OTUD1 (OTU deubiquitinase 1) is a member of the ovarian tumor (OTU) domain-containing family of proteins that deubiquitinate target substrates, playing a crucial role in various cellular processes such as cell signaling, DNA damage response, and immune regulation. Dysregulation of OTUD1 has been implicated in several diseases, including cancer, where it can influence tumor progression and resistance to therapy. Recent studies have highlighted OTUD1's involvement in modulating the ubiquitin-proteasome system, which is essential for maintaining protein homeostasis within cells. Given its significant role in key biological pathways, OTUD1 has emerged as an important target for therapeutic interventions. Investigating OTUD1's structural properties and enzymatic mechanisms through recombinant protein studies can provide vital insights into its functional relevance in health and disease. Understanding how OTUD1 interacts with other proteins and its substrate specificity may further elucidate its contributions to cellular dynamics, paving the way for novel therapeutic strategies aimed at inhibiting or enhancing its activity in various pathological conditions.
