Analytical Data
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基因名
XAB1
- Application
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别名
XAB1；MBDIN；GPN-loop GTPase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HCN4
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表达区间
1-374aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMAASAA AAELQASGGP RHPVCLLVLG MAGSGKTTFV QRLTGHLHAQ GTPPYVINLD PAVHEVPFPA NIDIRDTVKY KEVMKQYGLG PNGGIVTSLN LFATRFDQVM KFIEKAQNMS KYVLIDTPGQ IEVFTWSASG TIITEALASS FPTVVIYVMD TSRSTNPVTF MSNMLYACSI LYKTKLPFIV VMNKTDIIDH SFAVEWMQDF EAFQDALNQE TTYVSNLTRS MSLVLDEFYS SLRVVGVSAV LGTGLDELFV QVTSAAEEYE REYRPEYERL KKSLANAESQ QQREQLERLR KDMGSVALDA GTAKDSLSPV LHPSDLILTR GTLDEEDEEA DSDTDDIDHR VTEESHEEPA FQNFMQESMA QYWKRNNK
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分子量
44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XAB1 (XPD-binding protein 1) is a crucial protein that plays a significant role in DNA repair and RNA processing, particularly in the context of maintaining genomic stability. It interacts with various components of the nucleotide excision repair (NER) pathway and is known to associate with the XPD helicase, an essential element for unwinding DNA during repair processes. The study of XAB1 has gained momentum due to its implications in various cellular processes and its potential impact on cancer biology. Mutations or dysregulation of XAB1 can lead to impaired NER, increasing susceptibility to DNA damage and ultimately contributing to tumorigenesis. Recent research has focused on elucidating the structural and functional aspects of XAB1, including its role in splicing and interactions with RNA polymerase II during transcription. Understanding the intricacies of XAB1's function could provide insights into targeted therapies for cancers associated with DNA damage repair deficiencies. As researchers continue to explore XAB1, its potential as a biomarker for certain malignancies and a target for therapeutic intervention becomes increasingly apparent, highlighting the importance of ongoing studies in this area for advancing cancer treatment strategies.
