Analytical Data
-
Gene name
ATXN7L3
- Application
-
Alternative Names
AT7L3_HUMAN; Ataxin 7 like 3; Ataxin 7 like Protein 3; Ataxin-7-like Protein 3
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q14CW9
-
Expression Region
1-347aa
-
AA Sequence
MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYNNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN
-
Molecular Weight
38.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATXN7L3, a member of the ataxin gene family, is implicated in neurodegenerative disorders and has garnered attention due to its role in transcriptional regulation and the cellular response to stress. Research has shown that ATXN7L3 interacts with various proteins involved in critical cellular processes, including RNA processing and ubiquitination, which are essential for maintaining neuronal health. Its significance is underscored by studies linking mutations in ATXN7L3 to disorders such as spinocerebellar ataxia. The production of recombinant ATXN7L3 protein has become a focal point for understanding its biochemical function and the molecular mechanisms underlying its involvement in disease pathways. By generating this protein in vitro, researchers aim to elucidate its structure and interactions with other cellular components, paving the way for potential therapeutic targets. The study of ATXN7L3 not only enhances our understanding of neurodegeneration but also broadens the scope of molecular biology related to gene regulation and protein interactions in cellular systems.
