Analytical Data
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Gene name
IRAK1BP1
- Application
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Alternative Names
IRAK1BP1；Interleukin-1 receptor-associated kinase 1-binding Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5VVH5
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Expression Region
1-260aa
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AA Sequence
MSLQKTPPTR VFVELVPWAD RSRENNLASG RETLPGLRHP LSSTQAQTAT REVQVSGTSE VSAGPDRAQV VVRVSSTKEA AAEAKKSVCR RLDYITQSLQ QQGVQAENIT VTKDFRRVEN AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD SSVVISPPQF YHTPGSVENL RRQACLVAVE NAWRKAQEVC NLVGQTLGKP LLIKEEETKE WEGQIDDHQS SRLSSSLTVQ QKIKSATIHA ASKVFITFEV KGKEKRKKHL
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Molecular Weight
29.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRAK1BP1, or Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1, is a pivotal protein implicated in the regulation of inflammatory responses and immune signaling pathways. As a critical component of the innate immune system, it interacts with IRAK1, a key signaling molecule in the Toll-like receptor (TLR) pathway, which is essential for detecting pathogens and initiating immune responses. Research has shown that IRAK1BP1 plays a crucial role in modulating the activity of IRAK1, which can influence the production of pro-inflammatory cytokines. The dysregulation of this interaction may contribute to various inflammatory diseases and conditions, including autoimmune disorders and chronic inflammatory diseases. Therefore, the study of IRAK1BP1 as a recombinant protein presents a unique opportunity to dissect its functional mechanisms and explore its potential as a therapeutic target. By generating recombinant forms of IRAK1BP1, researchers aim to investigate its structural characteristics, binding affinities, and regulatory effects on IRAK1. This knowledge could facilitate the development of novel anti-inflammatory strategies, potentially leading to innovative treatments for diseases driven by aberrant immune responses. The growing interest in IRAK1BP1 underscores its significance in the field of immunology and highlights the need for further exploration into its biological functions and implications for human health.
