Analytical Data
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Gene name
PHC3
- Application
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Alternative Names
Early development regulator 3; Early development regulatory protein 3; EDR3; Homolog of polyhomeotic 3; HPH 3; hPH3; PH3; PHC 3 ; Phc3; PHC3_HUMAN; Polyhomeotic homolog 3 (Drosophila) ; Polyhomeotic homolog 3; Polyhomeotic-like protein 3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NDX5
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Expression Region
1-151 aa
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AA Sequence
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSVSSLNFFFLDLKF
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Molecular Weight
42.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PHC3 (Polyhomeotic homolog 3) is a member of the Polycomb group (PcG) proteins, which play essential roles in epigenetic regulation and chromatin remodeling. The research background for PHC3 recombinant proteins centers around its involvement in transcriptional repression, maintenance of stem cell pluripotency, and developmental processes. Dysregulation of PHC proteins, including PHC3, has been implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. Understanding the structural and functional characteristics of PHC3 can provide insights into its role in gene regulation and cellular differentiation. Moreover, producing recombinant PHC3 proteins enables researchers to investigate its molecular interactions, post-translational modifications, and influence on chromatin architecture, thereby contributing to the broader field of epigenetics and cancer biology. The implications of PHC3 in cell fate decisions, along with its potential as a biomarker or therapeutic target, underscore the need for in-depth studies into its biochemical properties and pathways, paving the way for innovative approaches in disease treatment and management.











