Analytical Data
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基因名
PHC3
- Application
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别名
Early development regulator 3; Early development regulatory protein 3; EDR3; Homolog of polyhomeotic 3; HPH 3; hPH3; PH3; PHC 3 ; Phc3; PHC3_HUMAN; Polyhomeotic homolog 3 (Drosophila) ; Polyhomeotic homolog 3; Polyhomeotic-like protein 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NDX5
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表达区间
1-151 aa
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氨基酸序列
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSVSSLNFFFLDLKF
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分子量
42.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PHC3 (Polyhomeotic homolog 3) is a member of the Polycomb group (PcG) proteins, which play essential roles in epigenetic regulation and chromatin remodeling. The research background for PHC3 recombinant proteins centers around its involvement in transcriptional repression, maintenance of stem cell pluripotency, and developmental processes. Dysregulation of PHC proteins, including PHC3, has been implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. Understanding the structural and functional characteristics of PHC3 can provide insights into its role in gene regulation and cellular differentiation. Moreover, producing recombinant PHC3 proteins enables researchers to investigate its molecular interactions, post-translational modifications, and influence on chromatin architecture, thereby contributing to the broader field of epigenetics and cancer biology. The implications of PHC3 in cell fate decisions, along with its potential as a biomarker or therapeutic target, underscore the need for in-depth studies into its biochemical properties and pathways, paving the way for innovative approaches in disease treatment and management.
