Analytical Data
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Gene name
FOXJ1
- Application
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Alternative Names
；
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92949
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Expression Region
1-421aa
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AA Sequence
MAESWLRLSG AGPAEEAGPE GGLEEPDALD DSLTSLQWLQ EFSILNAKAP ALPPGGTDPH GYHQVPGSAA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ YAERLLSGAF KKRRLPPVHI HPAFARQAAQ EPSAVPRAGP LTVNTEAQQL LREFEEATGE AGWGAGEGRL GHKRKQPLPK RVAKVPRPPS TLLPTPEEQG ELEPLKGNFD WEAIFDAGTL GGELGALEAL ELSPPLSPAS HVDVDLTIHG RHIDCPATWG PSVEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPLF EAGDATLASD LQDWASVGAF L
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Molecular Weight
45.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOXJ1, a member of the forkhead box (FOX) family of transcription factors, plays a crucial role in the regulation of ciliary genes and is essential for the development and function of motile cilia. These organelles are vital for various physiological processes, including mucociliary clearance in the respiratory system, fluid movement in the brain, and embryonic development. Defects in ciliary function can lead to a range of diseases, collectively termed ciliopathies, which include respiratory infections, infertility, and developmental disorders. Recent studies have highlighted FOXJ1 as a pivotal transcription factor that governs the expression of genes involved in cilium assembly and maintenance. Consequently, research into FOXJ1 recombinant protein has gained momentum, with scientists aiming to elucidate its structure, function, and interaction with other molecular players in ciliary signaling pathways. By producing FOXJ1 as a recombinant protein, researchers can investigate its functional properties in cell models, examine its role in ciliary biogenesis, and explore its potential as a therapeutic target for ciliopathies. Additionally, understanding the regulation of FOXJ1 expression may provide insights into the molecular mechanisms underlying various diseases linked to impaired ciliary function. This burgeoning field of research holds promise for developing novel strategies to combat ciliopathy-related disorders and enhance our understanding of ciliary biology. The exploration of FOXJ1's role and its downstream effects is expected to offer significant contributions to regenerative medicine and targeted therapies for ciliary dysfunctions.
