Analytical Data
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Gene name
UBQLN2
- Application
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Alternative Names
UBQLN2；N4BP4；Ubiquilin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UHD9
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Expression Region
1-624aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMAENGESSGPPRPSRGPAAAQGSAAAP AEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFA GKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSAS TPRSNSTPISTNSNPFGLGSLGGLAGLSSLGLSSTNFSELQSQMQQQLMA SPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNN PDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQE PMLNAAQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQ SSATTSTTTSTGSGSGNSSSNATGNTVAAANYVASIFSTPGMQSLLQQIT ENPQLIQNMLSAPYMRSMMQSLSQNPDLAAQMMLNSPLFTANPQLQEQMR PQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFT PGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGS TGSGGPTGPTVSSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPN PEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS
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Molecular Weight
68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UBQLN2 (Ubiquilin 2) is a member of the Ubiquilin family of proteins, which play critical roles in protein quality control and the ubiquitin-proteasome system. This protein is known for its involvement in various cellular processes, including protein homeostasis, endosomal trafficking, and autophagy. Recent studies have highlighted its significance in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where mutations in UBQLN2 have been linked to disease pathogenesis. The study of UBQLN2 recombinant protein has garnered interest due to its potential to elucidate the molecular mechanisms underlying these disorders. Recombinant UBQLN2 proteins can be used to investigate the protein's structure-function relationships, its interactions with other cellular components, and its role in the clearance of misfolded proteins. Additionally, these studies may open new avenues for therapeutic interventions targeting UBQLN2 pathways in neurodegeneration. Understanding the functional dynamics of UBQLN2 through recombinant protein research is crucial for developing strategies to mitigate its dysregulation in disease contexts, thus underscoring the protein's relevance in both basic and applied biomedical research.
