Analytical Data
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基因名
UBQLN2
- Application
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别名
UBQLN2；N4BP4；Ubiquilin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHD9
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表达区间
1-624aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMAENGESSGPPRPSRGPAAAQGSAAAP AEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFA GKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSAS TPRSNSTPISTNSNPFGLGSLGGLAGLSSLGLSSTNFSELQSQMQQQLMA SPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNN PDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQE PMLNAAQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQ SSATTSTTTSTGSGSGNSSSNATGNTVAAANYVASIFSTPGMQSLLQQIT ENPQLIQNMLSAPYMRSMMQSLSQNPDLAAQMMLNSPLFTANPQLQEQMR PQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFT PGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGS TGSGGPTGPTVSSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPN PEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS
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分子量
68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBQLN2 (Ubiquilin 2) is a member of the Ubiquilin family of proteins, which play critical roles in protein quality control and the ubiquitin-proteasome system. This protein is known for its involvement in various cellular processes, including protein homeostasis, endosomal trafficking, and autophagy. Recent studies have highlighted its significance in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where mutations in UBQLN2 have been linked to disease pathogenesis. The study of UBQLN2 recombinant protein has garnered interest due to its potential to elucidate the molecular mechanisms underlying these disorders. Recombinant UBQLN2 proteins can be used to investigate the protein's structure-function relationships, its interactions with other cellular components, and its role in the clearance of misfolded proteins. Additionally, these studies may open new avenues for therapeutic interventions targeting UBQLN2 pathways in neurodegeneration. Understanding the functional dynamics of UBQLN2 through recombinant protein research is crucial for developing strategies to mitigate its dysregulation in disease contexts, thus underscoring the protein's relevance in both basic and applied biomedical research.
