Analytical Data
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基因名
H1
- Application
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别名
H1；H1FX；Histone H1.10
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IZA3
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表达区间
1-346aa
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氨基酸序列
MAPGSVTSDI SPSSTSTAGS SRSPESEKPG PSHGGVPPGG PSHSSLPVGR RHPPVLRMVL EALQAGEQRR GTSVAAIKLY ILHKYPTVDV LRFKYLLKQA LATGMRRGLL ARPLNSKARG ATGSFKLVPK HKKKIQPRKM APATAPRRAG EAKGKGPKKP SEAKEDPPNV GKVKKAAKRP AKVQKPPPKP GAATEKARKQ GGAAKDTRAQ SGEARKVPPK PDKAMRAPSS AGGLSRKAKA KGSRSSQGDA EAYRKTKAES KSSKPTASKV KNGAASPTKK KVVAKAKAPK AGQGPNTKAA APAKGSGSKV VPAHLSRKTE APKGPRKAGL PIKASSSKVS SQRAEA
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分子量
35.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
H1 histone proteins play a crucial role in the packaging of DNA within the nucleus, contributing to the formation of higher-order chromatin structures. As the major component of the nucleosome, H1 functions in stabilizing the nucleosome and regulating DNA accessibility, which is essential for processes such as transcription, replication, and repair. Research into H1 proteins has gained significant attention due to their involvement in various cellular processes and their potential implications in diseases, including cancer. Abnormal expression or mutation of H1 histones can lead to altered chromatin dynamics and, consequently, dysfunctional gene regulation. Studies have focused on deciphering the specific roles of different H1 variants, understanding their interactions with other chromatin components, and exploring their post-translational modifications. Furthermore, advances in molecular biology techniques have enabled researchers to investigate H1’s impact on epigenetic regulation and cellular differentiation, making it a vital target for therapeutic interventions. Overall, the exploration of H1 histone proteins not only enhances our fundamental understanding of chromatin biology but also opens avenues for novel diagnostic and treatment strategies in diseases associated with epigenetic abnormalities.
