Analytical Data
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Gene name
TAGAP
- Application
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Alternative Names
TAGAP；TAGAP1；T-cell activation Rho GTPase-activating Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N103
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Expression Region
1-731aa
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AA Sequence
MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE VKKRKKVLSW PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL PRPIQDILTI LCLKGPSTEG IFRRAANEKA RKELKEELNS GDAVDLERLP VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG ALEMQDEEDR IEALKQVADK LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN MLTLENDQSL SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA REVSPEPIVS TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS EGDFPVPRVG SRLESEEAED PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV LPRALVLKAF SSSSLDASSD SSPVASPSSP KRNFFSRHQS FTTKTEKGKP SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP RGVRKESQLA GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG SKEPLPGHGL SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES VQRNKRDCLV RRCSQPVFEA DQFQYAKESY I
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Molecular Weight
80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TAGAP (T-cell activation RhoGTPase-activating protein) is a crucial regulator of Rho family GTPases, which play significant roles in T-cell signaling, cytoskeletal dynamics, and cellular adhesion processes. Recent studies have highlighted the importance of TAGAP in immune responses, particularly in T-cell activation and differentiation. Dysregulation of TAGAP has been implicated in various autoimmune diseases and conditions associated with altered immune responses. The focus of research on TAGAP recombinant proteins is aimed at elucidating its precise mechanistic roles and interactions within T-cell signaling pathways. By expressing TAGAP as a recombinant protein, researchers can analyze its effects on RhoGTPase activity, assess its structural properties, and explore its potential as a therapeutic target. Understanding the functional dynamics of TAGAP could pave the way for novel strategies in manipulating immune responses, offering insights for both immunotherapy and vaccine development. The ultimate goal of this research is to harness the knowledge gained from TAGAP studies to develop innovative approaches for combating immune-related disorders and enhancing T-cell-based therapies.
