Analytical Data
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Gene name
SOX4
- Application
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Alternative Names
SOX4；Transcription factor SOX-4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q06945
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Expression Region
1-474aa
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AA Sequence
MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGGGGGASGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAEQAGAAALLPLGAAADHHSLYKARTPSASASASSAASASAALAAPGKHLAEKKVKRVYLFGGLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSPDAPSLSGRSSAASSPAAGRSPADHRGYASLRAASPAPSSAPSHASSSASSHSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOX4 (SRY-related HMG-box 4) is a transcription factor belonging to the SOX family, which plays a crucial role in embryonic development and cellular differentiation. It is implicated in various biological processes, including cell fate determination, stem cell maintenance, and tumorigenesis. Abnormal expression of SOX4 has been linked to several cancers, making it a significant target for cancer research. The study of recombinant SOX4 protein is essential for understanding its structure-function relationship and regulatory mechanisms. Researchers aim to produce and characterize this protein to investigate its role in signaling pathways, gene regulation, and developmental processes. The ability to express the SOX4 protein in a recombinant form allows for detailed biochemical analyses, including binding affinities and interactions with other proteins or DNA. Furthermore, understanding the molecular basis of SOX4 function could lead to potential therapeutic applications, such as targeting its pathways in cancer treatment. Given the increasing emphasis on precision medicine and targeted therapies, elucidating the precise roles of transcription factors like SOX4 could provide valuable insights into the development of novel strategies for cancer intervention and other diseases associated with its dysregulation.
