Analytical Data
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Gene name
ARRDC1
- Application
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Alternative Names
ARRD1_HUMAN; ARRDC 1; ARRDC1; Arrestin domain containing 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N5I2
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Expression Region
1-433aa
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AA Sequence
MGRVQLFEIS LSHGRVVYSP GEPLAGTVRV RLGAPLPFRA IRVTCIGSCG VSNKANDTAW VVEEGYFNSS LSLADKGSLP AGEHSFPFQF LLPATAPTSF EGPFGKIVHQ VRAAIHTPRF SKDHKCSLVF YILSPLNLNS IPDIEQPNVA SATKKFSYKL VKTGSVVLTA STDLRGYVVG QALQLHADVE NQSGKDTSPV VASLLQKVSY KAKRWIHDVR TIAEVEGAGV KAWRRAQWHE QILVPALPQS ALPGCSLIHI DYYLQVSLKA PEATVTLPVF IGNIAVNHAP VSPRPGLGLP PGAPPLVVPS APPQEEAEAE AAAGGPHFLD PVFLSTKSHS QRQPLLATLS SVPGAPEPCP QDGSPASHPL HPPLCISTGA TVPYFAEGSG GPVPTTSTLI LPPEYSSWGY PYEAPPSYEQ SCGGVEPSLT PES
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Molecular Weight
45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARRDC1, or Arrestin Domain Containing 1, is a protein that has garnered interest in the field of cellular signaling and molecular biology due to its role in regulating various pathways associated with receptor trafficking and degradation. This protein is part of the arrestin family and is known to interact with a variety of cell surface receptors, including G-protein coupled receptors (GPCRs). The study of ARRDC1 has implications in understanding its involvement in critical physiological processes and potential pathological conditions, including cancer and metabolic disorders. Recent research has highlighted ARRDC1's function in mediating the internalization of receptors, thereby influencing signaling outcomes and cellular responses. Additionally, its interaction with numerous signaling partners suggests that ARRDC1 may act as a hub in cellular networks, further emphasizing its importance in maintaining cellular homeostasis. Recombinant ARRDC1 protein has been expressed and characterized to elucidate its structural and functional properties, providing insights into its mechanisms of action and regulatory functions within the cell. As research continues to unveil the complexities of ARRDC1, it may offer new therapeutic avenues for diseases linked to dysregulated receptor signaling.
