Analytical Data
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基因名
CDK14
- Application
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别名
CDK14；KIAA0834；PFTK1；Cyclin-dependent kinase 14
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94921
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表达区间
1-469aa
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氨基酸序列
MCDLIEPQPA EKIGKMKKLR RTLSESFSRI ALKKDDTTFD EICVTKMSTR NCQGMDSVIK PLDTIPEDKK VRVQRTQSTF DPFEKPANQV KRVHSENNAC INFKTSSTGK ESPKVRRHSS PSSPTSPKFG KADSYEKLEK LGEGSYATVY KGKSKVNGKL VALKVIRLQE EEGTPFTAIR EASLLKGLKH ANIVLLHDII HTKETLTLVF EYVHTDLCQY MDKHPGGLHP DNVKLFLFQL LRGLSYIHQR YILHRDLKPQ NLLISDTGEL KLADFGLARA KSVPSHTYSN EVVTLWYRPP DVLLGSTEYS TCLDMWGVGC IFVEMIQGVA AFPGMKDIQD QLERIFLVLG TPNEDTWPGV HSLPHFKPER FTLYSSKNLR QAWNKLSYVN HAEDLASKLL QCSPKNRLSA QAALSHEYFS DLPPRLWELT DMSSIFTVPN VRLQPEAGES MRAFGKNNSY GKSLSNSKH
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分子量
53 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK14 (Cyclin-Dependent Kinase 14) is a member of the CDC2/CDK family of serine/threonine kinases, which play critical roles in cell cycle regulation and transcriptional control. Investigating CDK14 is particularly relevant due to its involvement in various cellular processes, including cell proliferation, differentiation, and response to stress. Recent studies have demonstrated that CDK14 is overexpressed in several types of cancers, suggesting that it may act as an oncogenic factor, making it a potential target for therapeutic interventions. Additionally, CDK14 is known to interact with RNA polymerase II, influencing alternative splicing and transcriptional regulation, which further underscores its importance in gene expression and cellular function. By producing and characterizing recombinant CDK14 protein, researchers aim to gain insights into its biochemical properties, regulatory mechanisms, and interaction networks. This research could provide valuable information for developing novel cancer therapies and understanding the broader implications of CDK14 in cellular homeostasis and disease. The increased focus on CDK14 also aligns with the growing interest in targeting specific kinases in cancer treatment and precision medicine approaches. Thus, the study of recombinant CDK14 not only furthers our understanding of basic cellular biology but also opens avenues for innovative therapeutic strategies in oncology.
