Analytical Data
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Gene name
UBE2A
- Application
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Alternative Names
UBE2A；RAD6A；Ubiquitin-conjugating enzyme E2 A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49459
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Expression Region
1-152aa
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AA Sequence
MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS PANSQAAQLY QENKREYEKR VSAIVEQSWR DC
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Molecular Weight
17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UBE2A, a member of the ubiquitin-conjugating enzyme family, plays a vital role in the ubiquitin-proteasome pathway, which regulates protein degradation and various cellular processes such as cell cycle progression, DNA repair, and signal transduction. The research on UBE2A has gained momentum due to its significant implications in multiple biological and pathological contexts, including its involvement in neurodevelopmental disorders and certain cancers. Mutations or dysregulation of UBE2A have been linked to conditions like X-linked intellectual disability and various tumorigenic processes, underscoring its importance as a target for therapeutic interventions. Studies have focused on elucidating the structure-function relationships of UBE2A and its interactions with ubiquitin, E3 ligases, and substrate proteins, which are crucial for understanding its mechanistic role in the ubiquitin system. Additionally, the exploration of UBE2A inhibitors or modulators holds promise for the development of novel treatment strategies for diseases arising from its aberrant activity. Consequently, research into UBE2A continues to evolve, aiming to uncover its full range of biological functions and therapeutic potential in human health and disease.
