Analytical Data
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基因名
UBE2A
- Application
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别名
UBE2A；RAD6A；Ubiquitin-conjugating enzyme E2 A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49459
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表达区间
1-152aa
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氨基酸序列
MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS PANSQAAQLY QENKREYEKR VSAIVEQSWR DC
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分子量
17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBE2A, a member of the ubiquitin-conjugating enzyme family, plays a vital role in the ubiquitin-proteasome pathway, which regulates protein degradation and various cellular processes such as cell cycle progression, DNA repair, and signal transduction. The research on UBE2A has gained momentum due to its significant implications in multiple biological and pathological contexts, including its involvement in neurodevelopmental disorders and certain cancers. Mutations or dysregulation of UBE2A have been linked to conditions like X-linked intellectual disability and various tumorigenic processes, underscoring its importance as a target for therapeutic interventions. Studies have focused on elucidating the structure-function relationships of UBE2A and its interactions with ubiquitin, E3 ligases, and substrate proteins, which are crucial for understanding its mechanistic role in the ubiquitin system. Additionally, the exploration of UBE2A inhibitors or modulators holds promise for the development of novel treatment strategies for diseases arising from its aberrant activity. Consequently, research into UBE2A continues to evolve, aiming to uncover its full range of biological functions and therapeutic potential in human health and disease.
