Analytical Data
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Gene name
ARMCX1
- Application
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Alternative Names
ARMCX 1; AD032; ALEX1; ARM Protein lost in epithelial cancers on chromosome X 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P291
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Expression Region
1-453aa
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AA Sequence
MGRTREAGCVAAGVVIGAGACYCVYRLAWGRDENEKIWDEDEESTDTSEIGVETVKGAKTNAGAGSGAKLQGDSEVKPEVSLGLEDCPGVKEKAHSGSHSGGGLEAKAKALFNTLKEQASAKAGKGARVGTISGNRTLAPSLPCPGGRGGGCHPTRSGSRAGGRASGKSKGKARSKSTRAPATTWPVRRGKFNFPYKIDDILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTKDPIIREKTYNALNNLSVNAENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDFFALLFLGNHFTKIQIMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNILTLFENINDNIKNEGLASSRKEFSRSSLFFLFKESGVCVKKIKALANHNDLVVKVKVLKVLTKL
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Molecular Weight
75.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARMCX1, or ARM cytoskeletal protein 1, is a member of the armadillo repeat-containing protein family, which is known for its role in various cellular processes, including cell adhesion, signaling, and cytoskeletal organization. Research into ARMCX1 has gained momentum due to its potential involvement in human health and disease. For instance, studies have suggested that ARMCX1 may play a role in neurodevelopment and is implicated in neurodegenerative disorders, where dysfunction in cytoskeletal dynamics and cellular signaling can contribute to disease progression. Additionally, ARMCX1 has been linked to certain cancers, where altered expression or mutations may affect tumor growth and metastasis. Given its significant roles, the recombinant expression of ARMCX1 protein in various systems is critical for studying its structural and functional properties. This involves producing ARMCX1 in heterologous systems such as bacteria or mammalian cells to obtain the protein in sufficient quantities for biochemical assays and structural studies. Understanding the biological functions of ARMCX1 may provide insights into its mechanisms of action, paving the way for potential therapeutic strategies targeting related diseases. As such, ongoing research aims to elucidate the precise roles of ARMCX1 in cellular contexts and its contribution to pathophysiological conditions.
