Analytical Data
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基因名
PANX3
- Application
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别名
PANX3；Pannexin-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96QZ0
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表达区间
1-392aa
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氨基酸序列
MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
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分子量
44.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PANX3 (Pannexin 3) is a member of the pannexin family of proteins, which are integral membrane proteins that form gap junction-like channels, facilitating intercellular communication and the passage of ions and small molecules. Originally identified in various tissues, including bone and cartilage, PANX3 plays a critical role in cellular processes such as mechanosensation, apoptosis, and tissue homeostasis. Research has indicated that PANX3 is involved in the regulation of osteoblast and chondrocyte functions, making it a potential key player in bone development and joint health. Dysregulation of PANX3 expression has been implicated in various pathological conditions, including osteoarthritis and other degenerative joint diseases. Developing recombinant PANX3 proteins enables a deeper understanding of its functional properties, interactions with other cellular components, and its role in disease mechanisms. Furthermore, characterizing PANX3 at the molecular level may lead to novel therapeutic strategies targeting pannexin channels, which could be beneficial in enhancing bone regeneration or treating joint disorders. Thus, the study of recombinant PANX3 protein not only contributes to the fundamental biology of intercellular communication but also offers potential clinical applications in musculoskeletal health and regenerative medicine.
