Analytical Data
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Gene name
PANX3
- Application
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Alternative Names
PANX3；Pannexin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96QZ0
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Expression Region
1-392aa
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AA Sequence
MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
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Molecular Weight
44.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PANX3 (Pannexin 3) is a member of the pannexin family of proteins, which are integral membrane proteins that form gap junction-like channels, facilitating intercellular communication and the passage of ions and small molecules. Originally identified in various tissues, including bone and cartilage, PANX3 plays a critical role in cellular processes such as mechanosensation, apoptosis, and tissue homeostasis. Research has indicated that PANX3 is involved in the regulation of osteoblast and chondrocyte functions, making it a potential key player in bone development and joint health. Dysregulation of PANX3 expression has been implicated in various pathological conditions, including osteoarthritis and other degenerative joint diseases. Developing recombinant PANX3 proteins enables a deeper understanding of its functional properties, interactions with other cellular components, and its role in disease mechanisms. Furthermore, characterizing PANX3 at the molecular level may lead to novel therapeutic strategies targeting pannexin channels, which could be beneficial in enhancing bone regeneration or treating joint disorders. Thus, the study of recombinant PANX3 protein not only contributes to the fundamental biology of intercellular communication but also offers potential clinical applications in musculoskeletal health and regenerative medicine.
