Analytical Data
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Gene name
MTNR1C
- Application
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Alternative Names
MTNR1C；Melatonin receptor type 1C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49219
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Expression Region
1-420aa
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AA Sequence
MMEVNSTCLDCRTPGTIRTEQDAQDSASQGLTSALAVVLIFTIVVDVLGNILVILSVLRNKKLQNAGNLFVVSLSIADLVVAVYPYPVILIAIFQNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNQRSTWCYLGLTWILTIIAIVPNFFVGSLQYDPRIFSCTFAQTVSSSYTITVVVVHFIVPLSVVTFCYLRIWVLVIQVKHRVRQDFKQKLTQTDLRNFLTMFVVFVLFAVCWAPLNFIGLAVAINPFHVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEYKRILMSLLTPRLLFLDTSRGGTEGLKSKPSPAVTNNNQADMLGEARSLWLSRRNGAKMVIIIRPRKAQIAIIHQIFWPQSSWATCRQDTKITGEEDGCRELCKDGISQR
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Molecular Weight
47.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MTNR1C, also known as melatonin receptor 1C, is a member of the G protein-coupled receptor (GPCR) family that plays a crucial role in mediating the physiological effects of melatonin, a hormone primarily produced by the pineal gland. Research into MTNR1C has gained significant attention due to its involvement in various biological processes, including circadian rhythm regulation, reproductive functions, and seasonal reproductive adaptations in animals. The receptor is distinct from its counterparts, MTNR1A and MTNR1B, with unique expression patterns and functional implications in different tissues. Notably, MTNR1C has been implicated in several health conditions, including sleep disorders, mood disorders, and certain cancers, making it a potential target for therapeutic interventions. However, the limited availability of purified and functional MTNR1C proteins has hindered detailed studies of its signaling pathways and structural biology. Recent advancements in recombinant protein technology allow for the expression, purification, and characterization of MTNR1C, offering a valuable tool for elucidating its mechanisms of action and exploring its potential as a drug target. Understanding MTNR1C's function at a molecular level could lead to novel treatments for melatonin-related disorders and deeper insights into circadian biology. As research progresses, the development of MTNR1C recombinant proteins will facilitate the investigation of drug interactions and signaling cascades, enhancing our understanding of this important receptor and its role in health and disease.
