Analytical Data
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Gene name
TALDO1
- Application
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Alternative Names
TALDO1；TAL；Transaldolase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P37837
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Expression Region
1-337aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMSSSPVKRQRMESALDQLKQFTTVVADTGD FHAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGRKLGGSQEDQI KNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYK EAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAE AGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYK TIVMGASFRNTGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQ ASDLEKIHLDEKSFRWLHNEDQMAVEKLSDGIRKFAADAVKLERMLTERM FNAENGK
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Molecular Weight
40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TALDO1, or transaldolase 1, is a crucial enzyme involved in the pentose phosphate pathway (PPP), playing a key role in cellular metabolism by facilitating the interconversion of sugar phosphates. This enzyme is critical for maintaining cellular redox balance and producing ribose-5-phosphate, which is essential for nucleotide synthesis. Abnormalities in TALDO1 function can lead to various metabolic disorders, including a rare condition known as TALDO1 deficiency, characterized by a range of symptoms, including neurodevelopmental issues and hematological disorders. Recent research has focused on characterizing the recombinant form of TALDO1 to better understand its structural and functional properties, as well as to explore potential therapeutic interventions for TALDO1-related conditions. By producing and analyzing recombinant TALDO1, scientists aim to elucidate the molecular mechanisms underlying its enzymatic activity and stability while also investigating the effects of mutations associated with TALDO1 deficiency. This research is expected to provide insights into the enzyme's role in human metabolism and could pave the way for developing targeted therapies to address metabolic diseases linked to TALDO1 dysfunction. Overall, recombinant TALDO1 studies contribute significantly to the field of metabolic research, enhancing our understanding of enzymatic functions and their implications in health and disease.
