Analytical Data
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基因名
ADH3
- Application
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别名
ADH3；ADH3；Alcohol dehydrogenase 1C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P00326
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表达区间
1-375aa
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氨基酸序列
MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF
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分子量
66.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADH3, or alcohol dehydrogenase class III, is an enzyme that plays a crucial role in the metabolism of alcohols and aldehydes and is predominantly expressed in the liver and other tissues. Its significance extends beyond alcohol metabolism; it is also involved in the oxidation of various substrates, including retinol and fatty acids. Research on ADH3 is particularly important due to its implications in various physiological and pathological processes, including the metabolism of drugs and the development of certain diseases, such as alcoholic liver disease and cancer. ADH3 exhibits polymorphic variants, which can influence individual responses to alcohol and susceptibility to alcohol-related disorders. The development of recombinant ADH3 proteins has provided valuable tools for studying the structure-function relationships of the enzyme, its enzymatic activity, and its interactions with various substrates and inhibitors. These recombinant proteins are also useful for high-throughput screening in drug discovery and for understanding the enzyme's role in metabolic pathways. The study of ADH3 and its recombinant forms is essential for further elucidating its biological functions and therapeutic potential, thereby contributing to advancements in biochemistry, pharmacology, and personalized medicine.
