Analytical Data
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Gene name
DYRK3
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简介
DYRK3 is a dual-specificity protein kinase that dissociates membraneless organelles such as stress granules and nuclear speckles in mitosis. DYRK3 Protein, Human (sf9, His-GST) is the recombinant human-derived DYRK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
Dual specificity tyrosine-phosphorylation-regulated kinase 3; REDK; DYRK3
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43781
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Expression Region
M1-S588
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Protein Length
Full Length
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Molecular Weight
80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DYRK3 (dual-specificity tyrosine phosphorylation-regulated kinase 3) is a member of the DYRK family of kinases, which are known for their roles in various cellular processes, including cell growth, differentiation, and responses to stress. The significance of DYRK3 has been underscored in recent studies linking it to various diseases, particularly neurodegenerative disorders and cancers, where aberrant kinase activity can lead to pathological changes in cell behavior. Research into DYRK3 has gained momentum due to its potential as a therapeutic target, as inhibiting its activity may offer novel strategies for managing these conditions. Furthermore, DYRK3 is involved in the regulation of protein synthesis and stability, particularly in relation to the signaling pathways mediated by growth factors and hormones. Understanding the biochemical mechanisms of DYRK3 through recombinant protein studies is crucial for elucidating its function and regulation. Recombinant DYRK3 allows researchers to investigate its enzymatic properties, substrate specificity, and interaction with other cellular components in vitro. This knowledge could pave the way for the development of specific inhibitors or modulators, which in turn could lead to innovative treatments for diseases influenced by DYRK3 dysregulation. Overall, the study of DYRK3 as a recombinant protein highlights its importance in cellular signaling pathways and its potential impact on therapeutic interventions for various diseases.
