Analytical Data
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基因名
DYRK3
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简介
DYRK3 is a dual-specificity protein kinase that dissociates membraneless organelles such as stress granules and nuclear speckles in mitosis. DYRK3 Protein, Human (sf9, His-GST) is the recombinant human-derived DYRK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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别名
Dual specificity tyrosine-phosphorylation-regulated kinase 3; REDK; DYRK3
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43781
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表达区间
M1-S588
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蛋白长度
Full Length
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分子量
80 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DYRK3 (dual-specificity tyrosine phosphorylation-regulated kinase 3) is a member of the DYRK family of kinases, which are known for their roles in various cellular processes, including cell growth, differentiation, and responses to stress. The significance of DYRK3 has been underscored in recent studies linking it to various diseases, particularly neurodegenerative disorders and cancers, where aberrant kinase activity can lead to pathological changes in cell behavior. Research into DYRK3 has gained momentum due to its potential as a therapeutic target, as inhibiting its activity may offer novel strategies for managing these conditions. Furthermore, DYRK3 is involved in the regulation of protein synthesis and stability, particularly in relation to the signaling pathways mediated by growth factors and hormones. Understanding the biochemical mechanisms of DYRK3 through recombinant protein studies is crucial for elucidating its function and regulation. Recombinant DYRK3 allows researchers to investigate its enzymatic properties, substrate specificity, and interaction with other cellular components in vitro. This knowledge could pave the way for the development of specific inhibitors or modulators, which in turn could lead to innovative treatments for diseases influenced by DYRK3 dysregulation. Overall, the study of DYRK3 as a recombinant protein highlights its importance in cellular signaling pathways and its potential impact on therapeutic interventions for various diseases.












