Analytical Data
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基因名
NODAL
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简介
Nodal protein plays a key role in embryonic development and is indispensable for mesoderm formation and axial patterning. As a homodimer linked together by disulfide bonds, Nodal helps form the molecular framework that controls fundamental developmental pathways, ensuring the correct establishment of mesodermal tissue and axial structure during embryogenesis. NODAL Protein, Human is the recombinant human-derived NODAL protein, expressed by E. coli, with tag free.
- Application
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别名
HTX5; NODAL; Nodal homolog
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96S42
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表达区间
H238-L347
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蛋白长度
Full Length of Mature Protein
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分子量
14-15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NODAL is a member of the TGF-beta superfamily of secreted signaling proteins that plays a crucial role in early embryonic development and the establishment of the body plan in vertebrates. It is primarily involved in regulating processes such as mesoderm formation, endoderm specification, and germ layer patterning. The study of NODAL has gained significant interest due to its pivotal functions in developmental biology, including the induction of pluripotency and maintenance of stem cell characteristics. Dysregulation of NODAL signaling has been implicated in various developmental disorders and diseases, including cancer, highlighting its potential as a therapeutic target. Research has focused on the mechanisms of NODAL signaling pathways, its interactions with other morphogens, and the effects of NODAL on cellular behaviors such as proliferation, differentiation, and migration. Additionally, studies have explored the role of NODAL in tissue regeneration and its impact on the microenvironment of stem cells. Overall, the exploration of NODAL's functions and regulatory mechanisms continues to provide valuable insights into both developmental processes and the underlying causes of various pathologies.
