Analytical Data
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基因名
CBX5
- Application
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种属
Human
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表达系统
E. coli
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标签
N-10*His;C-Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P45973
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表达区间
M1-S191
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氨基酸序列
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS
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蛋白长度
Full Length
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分子量
29.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CBX5, also known as heterochromatin protein 1, is a crucial component of the cellular machinery involved in maintaining genome integrity and regulating gene expression. As a part of the chromatin structure, CBX5 plays a significant role in the formation of heterochromatin, which is essential for the repression of transposable elements and the maintenance of genomic stability. The study of CBX5 has garnered considerable attention due to its implications in various biological processes, including aging, tumorigenesis, and response to stress. Abnormalities in its expression or function have been linked to several diseases, particularly cancers, where it may contribute to altered gene expression profiles. Recent research has focused on understanding the molecular mechanisms by which CBX5 exerts its effects on chromatin dynamics, gene regulation, and cellular differentiation. Additionally, the development of CBX5 recombinant proteins has opened up new avenues for exploring its functional properties and potential therapeutic applications, making it a key target in epigenetic research. Through investigations into CBX5, scientists aim to unravel the complexities of chromatin biology and its broader implications in health and disease, contributing to the advancement of targeted therapies and novel diagnostic approaches.
