Analytical Data
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Gene name
UTP6
- Application
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Alternative Names
UTP6; C17orf40; HCA66; MHAT; U3 small nucleolar RNA-associated Protein 6 homolog; Hepatocellular carcinoma-associated antigen 66; Multiple hat domains Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NYH9
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Expression Region
2-597 aa
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AA Sequence
AEIIQERIE DRLPELEQLE RIGLFSHAEI KAIIKKASDL EYKIQRRTLF KEDFINYVQY EINLLELIQR RRTRIGYSFK KDEIENSIVH RVQGVFQRAS AKWKDDVQLW LSYVAFCKKW ATKTRLSKVF SAMLAIHSNK PALWIMAAKW EMEDRLSSES ARQLFLRALR FHPECPKLYK EYFRMELMHA EKLRKEKEEF EKASMDVENP DYSEEILKGE LAWIIYKNSV SIIKGAEFHV SLLSIAQLFD FAKDLQKEIY DDLQALHTDD PLTWDYVARR ELEIESQTEE QPTTKQAKAV EVGRKEERCC AVYEEAVKTL PTEAMWKCYI TFCLERFTKK SNSGFLRGKR LERTMTVFRK AHELKLLSEC QYKQLSVSLL CYNFLREALE VAVAGTELFR DSGTMWQLKL QVLIESKSPD IAMLFEEAFV HLKPQVCLPL WISWAEWSEG AKSQEDTEAV FKKALLAVIG ADSVTLKNKY LDWAYRSGGY KKARAVFKSL QESRPFSVDF FRKMIQFEKE QESCNMANIR EYYERALREF GSADSDLWMD YMKEELNHPL GRPENCGQIY WRAMKMLQGE SAEAFVAKHA MHQTGHL
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Molecular Weight
70.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UTP6 (U3 small nucleolar RNA-associated protein 6) is a key player in the biogenesis of ribosomes, essential for cellular function and growth. Research into UTP6 has gained momentum due to its involvement in the assembly of the small nucleolar ribonucleoprotein complexes that facilitate pre-rRNA processing. Mutations in UTP6 have been implicated in various diseases, including cancers and developmental disorders, highlighting its relevance in human health. The protein is part of a larger network of proteins and RNA that cooperate in the modification and processing of rRNA transcripts. This intricate mechanism underscores the importance of UTP6 in cellular homeostasis and gene expression. Recent studies using advanced techniques such as cryo-electron microscopy and X-ray crystallography have elucidated the structural and functional characteristics of UTP6, paving the way for potential therapeutic interventions targeting its pathways. Understanding the precise role of UTP6 in ribosome biogenesis not only contributes to our knowledge of fundamental cellular processes but also opens avenues for addressing the pathological conditions associated with its dysfunction. Given the critical nature of ribosome assembly in cellular physiology, ongoing research into UTP6 may provide insights into novel treatments for diseases linked to ribosomal dysregulation.
