Analytical Data
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Gene name
UTP18
- Application
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Alternative Names
CGI 48; U3 small nucleolar RNA associated Protein 18 homolog; U3 small nucleolar RNA-associated Protein 18 homolog; UTP 18; UTP18; UTP18 small subunit (SSU) processome component homolog; UTP18 small subunit processome component; UTP18_HUMAN; WD repeat containing Protein 50; WD repeat domain 50; WD repeat-containing Protein 50; WDR50
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5J1
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Expression Region
1-556 aa
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AA Sequence
MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP PARPSAAAAA IAVAAAEEER RLRQRNRLRL EEDKPAVERC LEELVFGDVE NDEDALLRRL RGPRVQEHED SGDSEVENEA KGNFPPQKKP VWVDEEDEDE EMVDMMNNRF RKDMMKNASE SKLSKDNLKK RLKEEFQHAM GGVPAWAETT KRKTSSDDES EEDEDDLLQR TGNFISTSTS LPRGILKMKN CQHANAERPT VARISSVQFH PGAQIVMVAG LDNAVSLFQV DGKTNPKIQS IYLERFPIFK ACFSANGEEV LATSTHSKVL YVYDMLAGKL IPVHQVRGLK EKIVRSFEVS PDGSFLLING IAGYLHLLAM KTKELIGSMK INGRVAASTF SSDSKKVYAS SGDGEVYVWD VNSRKCLNRF VDEGSLYGLS IATSRNGQYV ACGSNCGVVN IYNQDSCLQE TNPKPIKAIM NLVTGVTSLT FNPTTEILAI ASEKMKEAVR LVHLPSCTVF SNFPVIKNKN ISHVHTMDFS PRSGYFALGN EKGKALMYRL HHYSDF
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Molecular Weight
62 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UTP18 is a crucial component of the pre-ribosomal particle, playing an essential role in the assembly of ribosomal RNA and proteins into ribosomes, which are fundamental for protein synthesis in cells. The study of UTP18 and its function is significant because ribosome biogenesis is a highly regulated process, and any disruption can lead to various human diseases, including cancer. UTP18 is involved in early stages of ribosome assembly, particularly in facilitating the processing of rRNA and the incorporation of ribosomal proteins. Recent research has highlighted its interactions with other ribosome biogenesis factors and its role in maintaining cellular homeostasis. Understanding the structure-function relationship of UTP18, as well as its pathological implications, could provide insights into the molecular mechanisms underlying ribosomopathies. By exploring UTP18's mechanism of action and regulatory pathways, researchers aim to develop targeted therapeutic strategies to address conditions related to dysfunctional ribosome assembly, thereby contributing to the broader field of molecular biology and medicine.
