Analytical Data
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Gene name
UTP3
- Application
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Alternative Names
UTP3; CRLZ1; SAS10; Something about silencing Protein 10; Charged amino acid-rich leucine zipper 1; CRL1; Disrupter of silencing SAS10; UTP3 homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQZ2
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Expression Region
1-479 aa
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AA Sequence
MVGRSRRRGA AKWAAVRAKA GPTLTDENGD DLGLPPSPGD TSYYQDQVDD FHEARSRAAL AKGWNEVQSG DEEDGEEEEE EVLALDMDDE DDEDGGNAGE EEEEENADDD GGSSVQSEAE ASVDPSLSWG QRKKLYYDTD YGSKSRGRQS QQEAEEEERE EEEEAQIIQR RLAQALQEDD FGVAWVEAFA KPVPQVDEAE TRVVKDLAKV SVKEKLKMLR KESPELLELI EDLKVKLTEV KDELEPLLEL VEQGIIPPGK GSQYLRTKYN LYLNYCSNIS FYLILKARRV PAHGHPVIER LVTYRNLINK LSVVDQKLSS EIRHLLTLKD DAVKKELIPK AKSTKPKPKS VSKTSAAACA VTDLSDDSDF DEKAKLKYYK EIEDRQKLKR KKEENSTEEQ ALEDQNAKRA ITYQIAKNRG LTPRRKKIDR NPRVKHREKF RRAKIRRRGQ VREVRKEEQR YSGELSGIRA GVKKSIKLK
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Molecular Weight
54.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UTP3 (U3 small nucleolar RNA-associated protein 3) is an essential component in the biogenesis of ribosomal RNA, playing a crucial role in the assembly of ribosomal subunits in eukaryotic cells. Research into UTP3 and its recombinant forms has garnered significant attention due to its involvement in fundamental cellular processes and its potential implications in various diseases, including cancer. Understanding the structure and function of UTP3 through recombinant protein studies can provide insights into the mechanisms of ribosome assembly and nucleolar dynamics. Moreover, UTP3 is implicated in the regulation of cell proliferation and growth, making it a potential target for therapeutics aimed at correcting dysregulated ribosome synthesis in pathological conditions. The recombinant expression of UTP3 allows for the study of its biochemical properties, interactions with other ribosomal proteins, and alterations under different cellular stress conditions. This research is pivotal not only for elucidating the basic biology of ribosome assembly but also for discovering new biomarkers and drug targets in oncology and other proliferative disorders. Advances in recombinant UTP3 studies could foster the development of strategies for modulating its activity, contributing to novel treatment approaches in diseases characterized by abnormal ribosome function. Thus, the exploration of UTP3 as a recombinant protein continues to be an important avenue in cell biology and medical research.
