Analytical Data
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基因名
HIST2H2AC
- Application
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别名
HIST2H2AC；H2AFQ；HIST2H2AC；Histone H2A type 2-C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16777
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表达区间
2-129aa
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氨基酸序列
SGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YMAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK TESHKAKSK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST2H2AC is a member of the histone H2A family, primarily known for its role in the formation of nucleosomes, which are essential units of chromatin structure in eukaryotic cells. Histones are key regulators of gene expression, DNA repair, and replication, influencing various cellular processes through their post-translational modifications and interactions with DNA. The study of HIST2H2AC, particularly in the context of human health and disease, has gained significance given its involvement in epigenetic regulation and chromatin dynamics. Abnormal histone modifications have been linked to various cancers and genetic disorders, making the understanding of HIST2H2AC's function crucial. Recent advancements in recombinant protein technology have enabled the production of purified HIST2H2AC, facilitating detailed investigations into its structural properties, post-translational modifications, and interactions with other chromatin-associated proteins. Such studies aim to elucidate the mechanisms by which this histone variant contributes to chromatin organization and function, with potential implications for developing therapeutic strategies targeting epigenetic mechanisms in cancer and other diseases.
