Analytical Data
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基因名
USP39
- Application
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别名
65K; CGI 21; CGI-21; FLJ33136; HSPC332; Inactive ubiquitin specific peptidase 39; Inactive ubiquitin-specific peptidase 39; MGC75069; PRO2855; S. CEREVISIAE. HOMOLOG OF SAD1; SAD1; SAD1 homolog; Small nuclear ribonucleoProtein 65kDa (U4/U6.U5); snRNP ASSEMBLY DEFECTIVE 1; SnRNP assembly defective 1 homolog; SNRNP65; SNUT2_HUMAN; U4/U6.U5 tri snRNP associated 65 kDa Protein; U4/U6.U5 tri snRNP associated Protein 2; U4/U6.U5 tri-snRNP-associated 65 kDa Protein; U4/U6.U5 tri-snRNP-associated Protein 2; Ubiquitin specific peptidase 39; Ubiquitin specific protease 39; USP39
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q53GS9
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表达区间
1-565 aa
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氨基酸序列
MSGRSKRESR GSTRGKRESE SRGSSGRVKR ERDREREPEA ASSRGSPVRV KREFEPASAR EAPASVVPFV RVKREREVDE DSEPEREVRA KNGRVDSEDR RSRHCPYLDT INRSVLDFDF EKLCSISLSH INAYACLVCG KYFQGRGLKS HAYIHSVQFS HHVFLNLHTL KFYCLPDNYE IIDSSLEDIT YVLKPTFTKQ QIANLDKQAK LSRAYDGTTY LPGIVGLNNI KANDYANAVL QALSNVPPLR NYFLEEDNYK NIKRPPGDIM FLLVQRFGEL MRKLWNPRNF KAHVSPHEML QAVVLCSKKT FQITKQGDGV DFLSWFLNAL HSALGGTKKK KKTIVTDVFQ GSMRIFTKKL PHPDLPAEEK EQLLHNDEYQ ETMVESTFMY LTLDLPTAPL YKDEKEQLII PQVPLFNILA KFNGITEKEY KTYKENFLKR FQLTKLPPYL IFCIKRFTKN NFFVEKNPTI VNFPITNVDL REYLSEEVQA VHKNTTYDLI ANIVHDGKPS EGSYRIHVLH HGTGKWYELQ DLQVTDILPQ MITLSEAYIQ IWKRRDNDET NQQGA
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分子量
65.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
USP39 (Ubiquitin-specific protease 39) is a member of the ubiquitin-proteasome system, which plays a crucial role in the regulation of protein degradation, cell cycle progression, and various cellular processes. Dysregulation of USP39 has been implicated in a variety of diseases, including cancer, where altered ubiquitin signaling can contribute to tumorigenesis and metastasis. Research has shown that USP39 can influence the stability of key regulatory proteins by removing ubiquitin moieties, thereby regulating their degradation and activity. Understanding the molecular mechanisms by which USP39 functions can provide insights into its role in disease development and progression. Additionally, the exploration of USP39's potential as a therapeutic target is of growing interest, as inhibitors of USP39 could offer new strategies for treating cancers and other disorders where this enzyme is misregulated. Studies involving the characterization and functional analysis of recombinantly expressed USP39 protein are essential to elucidate its substrate specificity, enzymatic activity, and interactions with other cellular proteins. This research aims to provide a detailed understanding of the biochemical properties of USP39, which could pave the way for the development of novel therapeutic interventions aimed at modulating its activity in disease contexts.
